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| 標題: | Antidiarrheal Potential of Viola canescens: In Vivo and In Silico Approaches |
| 作者: | Ahmad, Imtiaz
Alotaibi, Bader S.
Malak, Nosheen
Asad, Fayaz
Ullah, Barkat
Nasreen, Nasreen
Khan, Adil
Chen, Chien-Chin |
| 貢獻者: | Bacha Khan Univ Charsadda, Dept Bot & Zool
Univ Peshawar, Dept Bot
Shaqra Univ, Coll Appl Med Sci, Departmet Labs Sci
Abdul Wali Khan Univ Mardan, Dept Zool
Islamia Coll Univ Peshawar, Dept Bot
Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Natl Cheng Kung Univ, Dept Biotechnol & Bioind Sci
Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, PhD Program Translat Med |
| 關鍵字: | antidiarrheal
Viola canescens
quercetin
violanthin
charcoal assay
molecular docking
phytocompounds |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:03:39 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Viola canescens Wall. is an important medicinal plant with reported therapeutic benefits. The current work sought to investigate the antidiarrheal properties of V. canescens extracts both in vivo and in silico. This study applied molecular docking to unravel the molecular mechanism of V. canescens and to find the most effective phytocompounds with antidiarrheal effects. The antidiarrheal activity of V. canescens was assessed utilizing the castor oil-induced diarrhea assay and the charcoal meal assay. Antidiarrheal characteristics were evaluated by measuring parameters such as intestinal motility, fecal score, and hypersecretion. The V. canescens extract had a dose-dependent and statistically significant impact in the charcoal meal assay and castor oil-induced diarrhea assay. In the castor oil-induced diarrhea assay, the ethyl acetate fraction (65.96%) showed the highest percentage of defecation inhibition at the highest dose (300 mg/kg (bw)), followed by the uncorrected crystalline compound (63.83%), crude alkaloids (63.83%), chloroform fraction (63.83%), and crude flavonoids (55.32%), while the aqueous fraction (40.43%) and n-Hexane fraction (42.55%) revealed the lowest antidiarrheal potential. In addition, the molecular docking investigation showed emetine, quercetin, and violanthin, isolated chemicals of V. canescens, to have the highest binding affinity to the target mu and delta opioid receptors with significant inhibitory capacity. These pharmacologically active metabolites in V. canescens were effective in treating diarrhea. This study lends credence to the traditional usage of V. canescens in treating gastrointestinal disorders. |
| 關聯: | Pharmaceuticals, v.16, n.4, Article 489 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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