Antidiarrheal Potential of Viola canescens: In Vivo and In Silico Approaches

doi:10.3390/ph16040489

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/34797

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標題:	Antidiarrheal Potential of Viola canescens: In Vivo and In Silico Approaches
作者:	Ahmad, Imtiaz Alotaibi, Bader S. Malak, Nosheen Asad, Fayaz Ullah, Barkat Nasreen, Nasreen Khan, Adil Chen, Chien-Chin
貢獻者:	Bacha Khan Univ Charsadda, Dept Bot & Zool Univ Peshawar, Dept Bot Shaqra Univ, Coll Appl Med Sci, Departmet Labs Sci Abdul Wali Khan Univ Mardan, Dept Zool Islamia Coll Univ Peshawar, Dept Bot Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Natl Cheng Kung Univ, Dept Biotechnol & Bioind Sci Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, PhD Program Translat Med
關鍵字:	antidiarrheal Viola canescens quercetin violanthin charcoal assay molecular docking phytocompounds
日期:	2023
上傳時間:	2024-12-25 11:03:39 (UTC+8)
出版者:	MDPI
摘要:	Viola canescens Wall. is an important medicinal plant with reported therapeutic benefits. The current work sought to investigate the antidiarrheal properties of V. canescens extracts both in vivo and in silico. This study applied molecular docking to unravel the molecular mechanism of V. canescens and to find the most effective phytocompounds with antidiarrheal effects. The antidiarrheal activity of V. canescens was assessed utilizing the castor oil-induced diarrhea assay and the charcoal meal assay. Antidiarrheal characteristics were evaluated by measuring parameters such as intestinal motility, fecal score, and hypersecretion. The V. canescens extract had a dose-dependent and statistically significant impact in the charcoal meal assay and castor oil-induced diarrhea assay. In the castor oil-induced diarrhea assay, the ethyl acetate fraction (65.96%) showed the highest percentage of defecation inhibition at the highest dose (300 mg/kg (bw)), followed by the uncorrected crystalline compound (63.83%), crude alkaloids (63.83%), chloroform fraction (63.83%), and crude flavonoids (55.32%), while the aqueous fraction (40.43%) and n-Hexane fraction (42.55%) revealed the lowest antidiarrheal potential. In addition, the molecular docking investigation showed emetine, quercetin, and violanthin, isolated chemicals of V. canescens, to have the highest binding affinity to the target mu and delta opioid receptors with significant inhibitory capacity. These pharmacologically active metabolites in V. canescens were effective in treating diarrhea. This study lends credence to the traditional usage of V. canescens in treating gastrointestinal disorders.
關聯:	Pharmaceuticals, v.16, n.4, Article 489
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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