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| 標題: | Inverse Probability of Treatment Weighting in 5-Year Quality-of-Life Comparison among Three Surgical Procedures for Hepatocellular Carcinoma |
| 作者: | Chang, Der-Ming
Chen, Yu-Fu
Chen, Hong-Yaw
Chiu, Chong-Chi
Lee, King-Teh
Wang, Jhi-Joung
Sun, Ding-Ping
Lee, Hao-Hsien
Shiu, Yu-Tsz
Chen, I-Te
Shi, Hon-Yi |
| 貢獻者: | Yuans Gen Hosp, Dept Surg, Div Digest Surg
Yuans Gen Hosp, Dept Clin Educ & Res
I Shou Univ, Coll Med, Sch Med
E Da Canc Hosp, Dept Med Educ & Res
Kaohsiung Med Univ Hosp, Dept Surg, Div Hepatobiliary Surg
Kaohsiung Med Univ, Dept Healthcare Adm & Med Informat
Chi Mei Med Ctr, Dept Med Res
Chi Mei Med Ctr, Dept Gen Surg
Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Natl Sun Yat Sen Univ, Dept Business Management
Kaohsiung Med Univ Hosp, Dept Med Res
China Med Univ, China Med Univ Hosp, Dept Med Res |
| 關鍵字: | quality of life
hepatocellular carcinoma
surgery
generalized estimating equations |
| 日期: | 2023 |
| 上傳時間: | 2024-12-25 11:03:32 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Simple Summary In patients who had undergone resection for hepatocellular carcinoma (HCC), scores for most quality-of-life (QOL) subscales were significantly improved by 6 months after resection; QOL scores then remained stable for the rest of the 5-year period of this study. The QOL improvements after laparoscopic surgery or robotic surgery were much larger than improvements after open surgery. Between the 2nd and 5th year postsurgery, however, QOL improvements were larger in robotic surgery patients compared to laparoscopic surgery patients. This prospective longitudinal cohort study analyzed long-term changes in individual subscales of quality-of-life (QOL) measures and explored whether these changes were related to effective QOL predictors after hepatocellular carcinoma (HCC) surgery. All 520 HCC patients in this study had completed QOL surveys before surgery and at 6 months, 2 years, and 5 years after surgery. Generalized estimating equation models were used to compare the 5-year QOL among the three HCC surgical procedures. The QOL was significantly (p < 0.05) improved at 6 months after HCC surgery but plateaued at 2-5 years after surgery. In postoperative surveys, the effect size was largest in the nausea and vomiting subscales in patients who had received robotic surgery, and the effect size was smallest in the dyspnea subscale in patients who had received open surgery. It revealed the following explanatory variables for postoperative QOL: surgical procedure type, gender, age, hepatitis C, smoking, tumor stage, postoperative recurrence, and preoperative QOL. The comparisons revealed that, when evaluating QOL after HCC surgery, several factors other than the surgery itself should be considered. The analysis results also implied that postoperative quality of life might depend not only on the success of the surgical procedure, but also on preoperative quality of life. |
| 關聯: | Cancers, v.15, n.1, Article 252 |
| 顯示於類別: | [行政單位] 456
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