頭頸部癌是全世界排名第六之惡性腫瘤，國人排名第五之惡性腫瘤。目前的治療方式以手術切除為主，或於外科手術後放射線治療與化療兩者合併方式，然而對於大多數接受放射線治療的病患，放射線皮膚炎的產生幾乎是無法避免的。本計畫與業者合作，應用天然物資源，開發專屬功能性原料，以含降低肌膚發炎及提升皮膚保護修護力之功效性植萃之奈米乳液水凝膠，易乾及形成薄膜之劑型產品，期望產品能更廣泛的應用於皮膚修護及放射線皮膚炎之預防上。 Surgery, radiation, chemotherapy and co-therapy after surgery are commonly used for treatment in patients with head and neck cancers, but the skin is sensitive after exposure to radiation. Radiation therapy causes tissue damage and inflammatory reactions, and the complication has obvious implications for patients with head and neck cancer. The appropriate treatment of radiotherapy dermatitis is an important element of current multi-disciplinary treatment. The current preparations for radiation dermatitis are limited, and most of them are steroid-based, antibacterial, moisturizing, and silver ion-based dressings. Patients still suffer from pain, skin ulcers and scarring after use, and the therapeutic effects are limited. Moreover, many ointment prices are expensive, and patients often can't afford it. The laboratory develops products that can be used comprehensively during the preventive phase and during radiation therapy. We screen for a plant extract to reduce inflammation and enhance skin protection, further study to reduce sensitivity and pain, improve cell repair and wound healing on the skin. We are also developing a nanoemulsion-hydrogel containing functional plant extracts that are easy to dry and film and recruiting patients with radiotherapy dermatitis to test the efficacy of the product. We hope that microemulsion gel can be more widely used in skin repair and prevention of radiation dermatitis, helping patients to resist the concomitant reactions of dermatitis caused by radiotherapy treatment.
