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| 標題: | In Vitro and In Vivo Nephroprotective Effects of Nelumbo nucifera Seedpod Extract against Cisplatin-Induced Renal Injury |
| 作者: | Chen, Jui-Yi
Tsai, Chia-Lin
Tseng, Chiao-Yun
Yu, Pei-Rong
Chang, Yu-Hsuan
Wong, Yue-Ching
Lin, Hui-Hsuan
Chen, Jing-Hsien |
| 貢獻者: | Chi Mei Hospital
Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
Chung Shan Medical University
Chung Shan Medical University Hospital |
| 關鍵字: | dna-damage response
induced nephrotoxicity
oxidative stress
cytochrome-c
apoptosis
platinum
mechanisms
quercetin
cells
inhibition |
| 日期: | 2022 |
| 上傳時間: | 2023-12-11 14:05:05 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Cisplatin has been considered a chemotherapeutic drug for treating human tumors, and one of the noteworthy side effects of cisplatin is nephrotoxicity. Amelioration of cisplatin-induced nephrotoxicity is necessary. Lotus seedpod extract (LSE) mainly composed of quercetin-3-glucuronide has been revealed for antioxidant and anti-tumor effects. However, the effects of LSE on cisplatin-induced nephrotoxicity are still unknown. This study aims to explore the in vitro and in vivo protective effect and possible mechanism of LSE on cisplatin-induced nephrotoxicity. Results showed that co-treatment of LSE with cisplatin raised the viability of rat renal tubular epithelial NRK-52E cells and decreased oxidative stress and cell apoptosis when compared to the cells treated with cisplatin alone. The molecular mechanisms analyzed found that LSE could reduce the expressions of apoptotic factors, including Bax, Bad, t-Bid, and caspases. In the in vivo study, LSE improved the cisplatin-induced levels of serum markers of kidney function, glomerular atrophy, and the degree of apoptosis in the kidneys. This is the first study to display that LSE prevents cisplatin-induced nephrotoxicity by reducing oxidative stress and apoptosis. Thus, LSE could be a novel and natural chemoprotective agent for cisplatin chemotherapy in the future. |
| 關聯: | PLANTS-BASEL, v.11, n.23, pp.3357 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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