In Vitro and In Vivo Nephroprotective Effects of Nelumbo nucifera Seedpod Extract against Cisplatin-Induced Renal Injury

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標題:	In Vitro and In Vivo Nephroprotective Effects of Nelumbo nucifera Seedpod Extract against Cisplatin-Induced Renal Injury
作者:	Chen, Jui-Yi Tsai, Chia-Lin Tseng, Chiao-Yun Yu, Pei-Rong Chang, Yu-Hsuan Wong, Yue-Ching Lin, Hui-Hsuan Chen, Jing-Hsien
貢獻者:	Chi Mei Hospital Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Chung Shan Medical University Chung Shan Medical University Hospital
關鍵字:	dna-damage response induced nephrotoxicity oxidative stress cytochrome-c apoptosis platinum mechanisms quercetin cells inhibition
日期:	2022
上傳時間:	2023-12-11 14:05:05 (UTC+8)
出版者:	MDPI
摘要:	Cisplatin has been considered a chemotherapeutic drug for treating human tumors, and one of the noteworthy side effects of cisplatin is nephrotoxicity. Amelioration of cisplatin-induced nephrotoxicity is necessary. Lotus seedpod extract (LSE) mainly composed of quercetin-3-glucuronide has been revealed for antioxidant and anti-tumor effects. However, the effects of LSE on cisplatin-induced nephrotoxicity are still unknown. This study aims to explore the in vitro and in vivo protective effect and possible mechanism of LSE on cisplatin-induced nephrotoxicity. Results showed that co-treatment of LSE with cisplatin raised the viability of rat renal tubular epithelial NRK-52E cells and decreased oxidative stress and cell apoptosis when compared to the cells treated with cisplatin alone. The molecular mechanisms analyzed found that LSE could reduce the expressions of apoptotic factors, including Bax, Bad, t-Bid, and caspases. In the in vivo study, LSE improved the cisplatin-induced levels of serum markers of kidney function, glomerular atrophy, and the degree of apoptosis in the kidneys. This is the first study to display that LSE prevents cisplatin-induced nephrotoxicity by reducing oxidative stress and apoptosis. Thus, LSE could be a novel and natural chemoprotective agent for cisplatin chemotherapy in the future.
關聯:	PLANTS-BASEL, v.11, n.23, pp.3357
显示于类别:	[保健營養系(所) ] 期刊論文

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