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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34684


    標題: A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh
    作者: Wu, Jiumn-Yih
    Ding, Hsiou-Yu
    Wang, Tzi-Yuan
    Hsu, Min-Hui
    Chang, Te-Sheng
    貢獻者: Department of Cosmetic Science, Chia Nan University of Pharmacy & Science
    Academia Sinica - Taiwan
    National University Tainan
    關鍵字: polygonum-multiflorum thunb.
    tyrosinase
    melanogenesis
    activation
    roots
    日期: 2022
    上傳時間: 2023-12-11 14:05:03 (UTC+8)
    出版者: MDPI
    摘要: Ha-Soo-Oh is a traditional Chinese medicine prepared from the roots of Polygonum multiflorum Thunb. The herb extract has been widely used in Asian countries as a tonic agent and nutritional supplement for centuries. To identify new bioactive compounds in Chinese herbs, the biotransformation-guided purification (BGP) process was applied to Ha-Soo-Oh with Bacillus megaterium tyrosinase (BmTYR) as a biocatalyst. The result showed that a major biotransformed compound could be purified using the BGP process with preparative high-performance liquid chromatography (HPLC), and it was confirmed as a new compound, 2,3,5,3',4'-pentahydroxystilbene-2-O-beta-glucoside (PSG) following mass and nucleic magnetic resonance (NMR) spectral analyses. PSG was further confirmed as a biotransformation product from 2,3,5,4'-tetrahydroxystilbene-2-O-beta-glucoside (TSG) by BmTYR. The new PSG exhibited 4.7-fold higher 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical scavenging activity than that of TSG. The present study highlights the potential usage of BGP in herbs to discover new bioactive compounds in the future.
    關聯: PLANTS-BASEL, v.11, n.17, 2286
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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