Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34684
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34684


    Title: A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh
    Authors: Wu, Jiumn-Yih
    Ding, Hsiou-Yu
    Wang, Tzi-Yuan
    Hsu, Min-Hui
    Chang, Te-Sheng
    Contributors: Department of Cosmetic Science, Chia Nan University of Pharmacy & Science
    Academia Sinica - Taiwan
    National University Tainan
    Keywords: polygonum-multiflorum thunb.
    tyrosinase
    melanogenesis
    activation
    roots
    Date: 2022
    Issue Date: 2023-12-11 14:05:03 (UTC+8)
    Publisher: MDPI
    Abstract: Ha-Soo-Oh is a traditional Chinese medicine prepared from the roots of Polygonum multiflorum Thunb. The herb extract has been widely used in Asian countries as a tonic agent and nutritional supplement for centuries. To identify new bioactive compounds in Chinese herbs, the biotransformation-guided purification (BGP) process was applied to Ha-Soo-Oh with Bacillus megaterium tyrosinase (BmTYR) as a biocatalyst. The result showed that a major biotransformed compound could be purified using the BGP process with preparative high-performance liquid chromatography (HPLC), and it was confirmed as a new compound, 2,3,5,3',4'-pentahydroxystilbene-2-O-beta-glucoside (PSG) following mass and nucleic magnetic resonance (NMR) spectral analyses. PSG was further confirmed as a biotransformation product from 2,3,5,4'-tetrahydroxystilbene-2-O-beta-glucoside (TSG) by BmTYR. The new PSG exhibited 4.7-fold higher 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical scavenging activity than that of TSG. The present study highlights the potential usage of BGP in herbs to discover new bioactive compounds in the future.
    Relation: PLANTS-BASEL, v.11, n.17, 2286
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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