NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis

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標題:	NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis
作者:	Sun, Ding-Ping Wu, Chia-Chun Chou, Chia-Lin Cheng, Li-Chin Wang, Wen-Ching Lin, Shiau-Shiuan Hung, Shih-Ting Tian, Yu-Feng Fang, Chia-Lang Lin, Kai-Yuan
貢獻者:	Chi Mei Hospital Department of Food Science and Technology, Chia Nan University of Pharmacy & Science Chi Mei Hospital Department of Pharmacy, Chia Nan University of Pharmacy & Science Chi Mei Hospital Taipei Medical University Taipei Medical University Taipei Medical University Hospital Chi Mei Hospital Taipei Medical University Chi Mei Hospital
關鍵字:	chromosome condensation protein overexpression condensins complex
日期:	2023
上傳時間:	2023-12-11 14:04:44 (UTC+8)
出版者:	ELSEVIER GMBH
摘要:	Colorectal cancer (CRC) is one of the types of cancers with a high incidence and is ranked the 3rd among men and 2nd among women worldwide. The purpose of this study was to investigate the correlation between non-SMC condensin I complex subunit G (NCAPG) and the prognosis of CRC and its function in CRC cells. The expression of NCAPG in colorectal tissues and cells was detected by immunoblotting and immunohistochemistry. Kaplan-Meier analysis was used to analyze the correlation between NCAPG and CRC prognosis. RNAi technology was used to investigate how NCAPG inhibition affected the proliferation and migration of CRC cells. Overexpression of NCAPG was positively correlated with several clinicopathologic characteristics, including T stage (P = 0.0198), M stage (P = 0.0005), and TNM stage (P < 0.0001). Kaplan-Meier analysis showed that the overexpression of NCAPG was also negatively correlated with disease-free survival and overall survival. In the culture of CRC cells, the knockdown of NCAPG inhibited the proliferation, migration, and invasion of the cells. Meanwhile, it was also found that NCAPG knockdown could interfere with G2/M-G1 transition in the cell cycle, resulting in the inhibition of cell proliferation. The overexpression of NCAPG may serve as a candidate biomarker for CRC prognosis. NCAPG is also a potential therapeutic target for CRC.
關聯:	Pathology - Research and Practice, v.241, January 2023, 154238
Appears in Collections:	[ 食品科技系 ] 期刊論文 [藥學系(所)] 期刊論文

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