NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/34678

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34678

Title:	NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis
Authors:	Sun, Ding-Ping Wu, Chia-Chun Chou, Chia-Lin Cheng, Li-Chin Wang, Wen-Ching Lin, Shiau-Shiuan Hung, Shih-Ting Tian, Yu-Feng Fang, Chia-Lang Lin, Kai-Yuan
Contributors:	Chi Mei Hospital Department of Food Science and Technology, Chia Nan University of Pharmacy & Science Chi Mei Hospital Department of Pharmacy, Chia Nan University of Pharmacy & Science Chi Mei Hospital Taipei Medical University Taipei Medical University Taipei Medical University Hospital Chi Mei Hospital Taipei Medical University Chi Mei Hospital
Keywords:	chromosome condensation protein overexpression condensins complex
Date:	2023
Issue Date:	2023-12-11 14:04:44 (UTC+8)
Publisher:	ELSEVIER GMBH
Abstract:	Colorectal cancer (CRC) is one of the types of cancers with a high incidence and is ranked the 3rd among men and 2nd among women worldwide. The purpose of this study was to investigate the correlation between non-SMC condensin I complex subunit G (NCAPG) and the prognosis of CRC and its function in CRC cells. The expression of NCAPG in colorectal tissues and cells was detected by immunoblotting and immunohistochemistry. Kaplan-Meier analysis was used to analyze the correlation between NCAPG and CRC prognosis. RNAi technology was used to investigate how NCAPG inhibition affected the proliferation and migration of CRC cells. Overexpression of NCAPG was positively correlated with several clinicopathologic characteristics, including T stage (P = 0.0198), M stage (P = 0.0005), and TNM stage (P < 0.0001). Kaplan-Meier analysis showed that the overexpression of NCAPG was also negatively correlated with disease-free survival and overall survival. In the culture of CRC cells, the knockdown of NCAPG inhibited the proliferation, migration, and invasion of the cells. Meanwhile, it was also found that NCAPG knockdown could interfere with G2/M-G1 transition in the cell cycle, resulting in the inhibition of cell proliferation. The overexpression of NCAPG may serve as a candidate biomarker for CRC prognosis. NCAPG is also a potential therapeutic target for CRC.
Relation:	Pathology - Research and Practice, v.241, January 2023, 154238
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Pharmacy] Periodical Articles

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