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    Title: Impact of Opioid-Free Anesthesia on Analgesia and Recovery Following Bariatric Surgery: a Meta-Analysis of Randomized Controlled Studies
    Authors: Hung, Kuo-Chuan
    Chiu, Chong-Chi
    Hsu, Chih-Wei
    Lin, Chien-Ming
    Liao, Shu-Wei
    Teng, I. -Chia
    Chen, I. -Wen
    Sun, Cheuk-Kwan
    Contributors: Chi Mei Hospital
    Recreation and Health Management, Chia Nan University of Pharmacy & Science
    E-Da Hospital
    I Shou University
    Chang Gung University
    Chang Gung Memorial Hospital
    Keywords: obstructive sleep-apnea
    postoperative nausea
    respiratory depression
    remifentanil infusion
    gastric bypass
    Date: 2022
    Issue Date: 2023-12-11 14:04:02 (UTC+8)
    Publisher: SPRINGER
    Abstract: This meta-analysis aimed at exploring the impact of opioid-free anesthesia (OFA) on pain score and opioid consumption in patients undergoing bariatric surgery (BS). Literature search identified eight eligible trials. Forest plot revealed a significantly lower pain score (mean difference (MD) = - 0.96, p = 0.0002; 318 patients), but not morphine consumption (MD = - 5.85 mg, p = 0.1; 318 patients) at postoperative 24 h in patients with OFA than in those without. Pooled analysis also showed a lower pain score (p = 0.002), morphine consumption (p = 0.0003) in the postanesthetic care unit, and risk of postoperative nausea/vomiting (p = 0.0003) in the OFA group compared to the controls. In conclusion, this meta-analysis demonstrated that opioid-free anesthesia improved pain outcomes immediately and at 24 h after surgery without a beneficial impact on opioid consumption at postoperative 24 h.
    Relation: OBESITY SURGERY, v.32, pp.3113–3124
    Appears in Collections:[Dept. of Recreation and Health-Care Management] Periodical Articles

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