Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34667
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    標題: Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis
    作者: Hung, Kuo-Chuan
    Wu, Shao-Chun
    Chiang, Min-Hsien
    Hsu, Chih-Wei
    Chen, Jui-Yi
    Huang, Ping-Wen
    Sun, Cheuk-Kwan
    貢獻者: Chi Mei Hospital
    Chia Nan University of Pharmacy & Science,Department of Hospital and Health Care Administration
    Chang Gung Memorial Hospital
    Chang Gung University
    Chang Gung University
    Chang Gung Memorial Hospital
    Chi Mei Hospital
    Chia Nan University of Pharmacy & Science,Department of Health and Nutrition
    Show Chwan Memorial Hospital
    E-Da Hospital
    I Shou University
    關鍵字: postoperative pain management
    sleeve gastrectomy
    obese-patients
    american-society
    morbidly obese
    opioids
    dexmedetomidine
    pharmacology
    anesthesia
    anxiety
    日期: 2022
    上傳時間: 2023-12-11 14:03:57 (UTC+8)
    出版者: SPRINGER
    摘要: This meta-analysis investigated the effect of oral gabapentinoids (i.e., pregabalin and gabapentin) on analgesic consumption (i.e., primary outcome) and pain relief (i.e., secondary outcome) in patients following bariatric surgery. Analysis of five eligible trials published between 2010 and 2019 including 363 participants receiving gabapentinoids revealed a significantly lower morphine consumption [mean difference (MD) = - 15.1 mg, p = 0.004; evidence certainty: low] and risk of nausea/vomiting [risk ratio (RR) = 0.49, p = 0.002; evidence certainty: high] at postoperative 6-24 h. There was also a lower pain score at postoperative 0-4 h (MD = - 1.41, p < 0.00001; evidence certainty: low) and 6-12 h (MD = - 0.9, p = 0.007; evidence certainty: low) compared with controls, while pain severity at postoperative 24 h was comparable between two groups. In summary, preoperative oral gabapentinoids optimized postoperative pain outcomes and reduced risk of nausea/vomiting following bariatric surgery.
    關聯: Obesity Surgery, v.32, pp.2734–2743 (2022)
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    [保健營養系(所) ] 期刊論文

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