Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis

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Title:	Analgesic Efficacy of Gabapentin and Pregabalin in Patients Undergoing Laparoscopic Bariatric Surgeries: a Systematic Review and Meta-analysis
Authors:	Hung, Kuo-Chuan Wu, Shao-Chun Chiang, Min-Hsien Hsu, Chih-Wei Chen, Jui-Yi Huang, Ping-Wen Sun, Cheuk-Kwan
Contributors:	Chi Mei Hospital Chia Nan University of Pharmacy & Science,Department of Hospital and Health Care Administration Chang Gung Memorial Hospital Chang Gung University Chang Gung University Chang Gung Memorial Hospital Chi Mei Hospital Chia Nan University of Pharmacy & Science,Department of Health and Nutrition Show Chwan Memorial Hospital E-Da Hospital I Shou University
Keywords:	postoperative pain management sleeve gastrectomy obese-patients american-society morbidly obese opioids dexmedetomidine pharmacology anesthesia anxiety
Date:	2022
Issue Date:	2023-12-11 14:03:57 (UTC+8)
Publisher:	SPRINGER
Abstract:	This meta-analysis investigated the effect of oral gabapentinoids (i.e., pregabalin and gabapentin) on analgesic consumption (i.e., primary outcome) and pain relief (i.e., secondary outcome) in patients following bariatric surgery. Analysis of five eligible trials published between 2010 and 2019 including 363 participants receiving gabapentinoids revealed a significantly lower morphine consumption [mean difference (MD) = - 15.1 mg, p = 0.004; evidence certainty: low] and risk of nausea/vomiting [risk ratio (RR) = 0.49, p = 0.002; evidence certainty: high] at postoperative 6-24 h. There was also a lower pain score at postoperative 0-4 h (MD = - 1.41, p < 0.00001; evidence certainty: low) and 6-12 h (MD = - 0.9, p = 0.007; evidence certainty: low) compared with controls, while pain severity at postoperative 24 h was comparable between two groups. In summary, preoperative oral gabapentinoids optimized postoperative pain outcomes and reduced risk of nausea/vomiting following bariatric surgery.
Relation:	Obesity Surgery, v.32, pp.2734–2743 (2022)
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles [Dept. of Health and Nutrition (including master's program)] Periodical Articles

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