Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid

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標題:	Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid
作者:	Tu, Ping-Chen Jiang, Wen-Ping Lin, Ming-Kuem Huang, Guan-Jhong Li, Yi-Jen Kuo, Yueh-Hsiung
貢獻者:	China Medical University Taiwan Department of Pharmacy, Chia Nan University of Pharmacy & Science Asia University Taiwan Chang Jung Christian University Asia University Taiwan China Medical University Taiwan
關鍵字:	4-acetylantroquinonol b cinnamomea derivatives mycelium cancer
日期:	2022
上傳時間:	2023-12-11 14:03:26 (UTC+8)
出版者:	MDPI
摘要:	Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A. camphorata on nitric oxide (NO) production in RAW 264.7 cells induced by polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of double-stranded RNA (dsRNA) known to be present in viral infection. A combination of bioactivity-guided isolation with an NMR-based identification led to the isolation of 4-acetylantroquinonol B (1), along with seven compounds. The structure of new compounds (4 and 5) was elucidated by spectroscopic experiments, including MS, IR, and NMR analysis. The anti-inflammatory activity of all isolated compounds was assessed at non-cytotoxic concentrations. 4-Acetylantroquinonol B (1) was the most potent compound against poly I:C-induced NO production in RAW 264.7 cells with an IC50 value of 0.57 +/- 0.06 mu M.
關聯:	MOLECULES, v.27, n.16, 5320
顯示於類別:	[藥學系(所)] 期刊論文

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