Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34658
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34658


    Title: Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid
    Authors: Tu, Ping-Chen
    Jiang, Wen-Ping
    Lin, Ming-Kuem
    Huang, Guan-Jhong
    Li, Yi-Jen
    Kuo, Yueh-Hsiung
    Contributors: China Medical University Taiwan
    Department of Pharmacy, Chia Nan University of Pharmacy & Science
    Asia University Taiwan
    Chang Jung Christian University
    Asia University Taiwan
    China Medical University Taiwan
    Keywords: 4-acetylantroquinonol b
    cinnamomea
    derivatives
    mycelium
    cancer
    Date: 2022
    Issue Date: 2023-12-11 14:03:26 (UTC+8)
    Publisher: MDPI
    Abstract: Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A. camphorata on nitric oxide (NO) production in RAW 264.7 cells induced by polyinosinic-polycytidylic acid (poly I:C), a synthetic analog of double-stranded RNA (dsRNA) known to be present in viral infection. A combination of bioactivity-guided isolation with an NMR-based identification led to the isolation of 4-acetylantroquinonol B (1), along with seven compounds. The structure of new compounds (4 and 5) was elucidated by spectroscopic experiments, including MS, IR, and NMR analysis. The anti-inflammatory activity of all isolated compounds was assessed at non-cytotoxic concentrations. 4-Acetylantroquinonol B (1) was the most potent compound against poly I:C-induced NO production in RAW 264.7 cells with an IC50 value of 0.57 +/- 0.06 mu M.
    Relation: MOLECULES, v.27, n.16, 5320
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

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