Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34656
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18076/20274 (89%)
造訪人次 : 4614581      線上人數 : 1290
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/34656


    標題: Djulis (Chenopodium formosanum) and Its Bioactive Compounds Protect Human Lung Epithelial A549 Cells from Oxidative Injury Induced by Particulate Matter via Nrf2 Signaling Pathway
    作者: Chu, Chin-Chen
    Chen, Shih-Ying
    Chyau, Charng-Cherng
    Wang, Shu-Chen
    Chu, Heuy-Ling
    Duh, Pin-Der
    貢獻者: Chi Mei Hospital
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Hungkuang University
    Department of Food Science and Technology, Chia Nan University of Pharmacy & Science
    關鍵字: antioxidant activity
    stress
    pm2.5
    system
    urban
    日期: 2022
    上傳時間: 2023-12-11 14:03:20 (UTC+8)
    出版者: MDPI
    摘要: The protective effects of water extracts of djulis (Chenopodium formosanum) (WECF) and their bioactive compounds on particulate matter (PM)-induced oxidative injury in A549 cells via the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling were investigated. WECF at 50-300 mu g/mL protected A549 cells from PM-induced cytotoxicity. The cytoprotection of WECF was associated with decreases in reactive oxygen species (ROS) generation, thiobarbituric acid reactive substances (TBARS) formation, and increases in superoxide dismutase (SOD) activity and glutathione (GSH) contents. WECF increased Nrf2 and heme oxygenase-1 (HO-1) expression in A549 cells exposed to PM. SP600125 (a JNK inhibitor) and U0126 (an ERK inhibitor) attenuated the WECF-induced Nrf2 and HO-1 expression. According to the HPLC-MS/MS analysis, rutin (2219.7 mu g/g) and quercetin derivatives (2648.2 mu g/g) were the most abundant bioactive compounds present in WECF. Rutin and quercetin ameliorated PM-induced oxidative stress in the cells. Collectively, the bioactive compounds present in WECF can protect A549 cells from PM-induced oxidative injury by upregulating Nrf2 and HO-1 via activation of the ERK and JUN signaling pathways.
    關聯: Molecules, v.27, n.1, Article 253
    顯示於類別:[保健營養系(所) ] 期刊論文
    [ 食品科技系 ] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML245檢視/開啟
    molecules-27-00253-v3.pdf2040KbAdobe PDF91檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋