Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34656
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    標題: Djulis (Chenopodium formosanum) and Its Bioactive Compounds Protect Human Lung Epithelial A549 Cells from Oxidative Injury Induced by Particulate Matter via Nrf2 Signaling Pathway
    作者: Chu, Chin-Chen
    Chen, Shih-Ying
    Chyau, Charng-Cherng
    Wang, Shu-Chen
    Chu, Heuy-Ling
    Duh, Pin-Der
    貢獻者: Chi Mei Hospital
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Hungkuang University
    Department of Food Science and Technology, Chia Nan University of Pharmacy & Science
    關鍵字: antioxidant activity
    stress
    pm2.5
    system
    urban
    日期: 2022
    上傳時間: 2023-12-11 14:03:20 (UTC+8)
    出版者: MDPI
    摘要: The protective effects of water extracts of djulis (Chenopodium formosanum) (WECF) and their bioactive compounds on particulate matter (PM)-induced oxidative injury in A549 cells via the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling were investigated. WECF at 50-300 mu g/mL protected A549 cells from PM-induced cytotoxicity. The cytoprotection of WECF was associated with decreases in reactive oxygen species (ROS) generation, thiobarbituric acid reactive substances (TBARS) formation, and increases in superoxide dismutase (SOD) activity and glutathione (GSH) contents. WECF increased Nrf2 and heme oxygenase-1 (HO-1) expression in A549 cells exposed to PM. SP600125 (a JNK inhibitor) and U0126 (an ERK inhibitor) attenuated the WECF-induced Nrf2 and HO-1 expression. According to the HPLC-MS/MS analysis, rutin (2219.7 mu g/g) and quercetin derivatives (2648.2 mu g/g) were the most abundant bioactive compounds present in WECF. Rutin and quercetin ameliorated PM-induced oxidative stress in the cells. Collectively, the bioactive compounds present in WECF can protect A549 cells from PM-induced oxidative injury by upregulating Nrf2 and HO-1 via activation of the ERK and JUN signaling pathways.
    關聯: Molecules, v.27, n.1, Article 253
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