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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34611


    標題: Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly
    作者: Cheng, Kuan-Chung
    Huang, Chih-Yuan
    Hsieh, Tsung-Chi
    Chiang, Hsueh-Cheng
    貢獻者: National Cheng Kung University
    National Cheng Kung University
    Department of Sport Management,College of Recreation and HealthManagement, Chia Nan University of Pharmacy & Science
    National Tsing Hua University
    關鍵字: alzheimers-disease
    channel blockers
    neurons
    dysregulation
    endocytosis
    apoptosis
    pathways
    mutation
    receptor
    release
    日期: 2022
    上傳時間: 2023-12-11 14:00:40 (UTC+8)
    出版者: WILEY
    摘要: Accumulated A beta is one of the hallmarks of Alzheimer's disease. Although accumulated results from in vivo and in vitro studies have shown that accumulated A beta causes learning and memory deficit, cell death, and lifespan reduction, the underlying mechanism remains elusive. In neurons, calcium dynamics is regulated by voltage-gated calcium channel (VGCC) and endoplasmic reticulum and is important for neuron survival and formation of learning and memory. The current study employs in vivo genetics to reveal the role of calcium regulation systems in A beta-induced behavioral damage. Our data shows that although increased VGCC improves learning and memory in A beta 42 flies, reduction of VGCC and Inositol trisphosphate receptors extends A beta 42 flies' lifespan and improves cell viability. The complex role of calcium regulation systems in A beta-induced damage suggests that the imbalance of calcium dynamic is one of the main factors to trigger learning and memory deficit and cell death in the disease.
    關聯: IUBMB Life, v.74, n.8, pp.CC2, pp.754-762
    Appears in Collections:[運動管理系] 期刊論文

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