Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly

doi:10.1002/iub.2621

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 運動管理系 > 期刊論文 > Item 310902800/34611

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標題:	Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly
作者:	Cheng, Kuan-Chung Huang, Chih-Yuan Hsieh, Tsung-Chi Chiang, Hsueh-Cheng
貢獻者:	National Cheng Kung University National Cheng Kung University Department of Sport Management,College of Recreation and HealthManagement, Chia Nan University of Pharmacy & Science National Tsing Hua University
關鍵字:	alzheimers-disease channel blockers neurons dysregulation endocytosis apoptosis pathways mutation receptor release
日期:	2022
上傳時間:	2023-12-11 14:00:40 (UTC+8)
出版者:	WILEY
摘要:	Accumulated A beta is one of the hallmarks of Alzheimer's disease. Although accumulated results from in vivo and in vitro studies have shown that accumulated A beta causes learning and memory deficit, cell death, and lifespan reduction, the underlying mechanism remains elusive. In neurons, calcium dynamics is regulated by voltage-gated calcium channel (VGCC) and endoplasmic reticulum and is important for neuron survival and formation of learning and memory. The current study employs in vivo genetics to reveal the role of calcium regulation systems in A beta-induced behavioral damage. Our data shows that although increased VGCC improves learning and memory in A beta 42 flies, reduction of VGCC and Inositol trisphosphate receptors extends A beta 42 flies' lifespan and improves cell viability. The complex role of calcium regulation systems in A beta-induced damage suggests that the imbalance of calcium dynamic is one of the main factors to trigger learning and memory deficit and cell death in the disease.
關聯:	IUBMB Life, v.74, n.8, pp.CC2, pp.754-762
显示于类别:	[運動管理系] 期刊論文

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