資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://ir.cnu.edu.tw/handle/310902800/34601
|
標題: | The Crosstalk of Long Non-Coding RNA and MicroRNA in Castration-Resistant and Neuroendocrine Prostate Cancer: Their Interaction and Clinical Importance |
作者: | Hu, Che-Yuan Wu, Kuan-Yu Lin, Tsung-Yen Chen, Chien-Chin |
貢獻者: | National Cheng Kung University National Cheng Kung University National Cheng Kung University Hospital National Cheng Kung University National Cheng Kung University Hospital Department of Cosmetic Science, Chia Nan University of Pharmacy & Science |
關鍵字: | epithelial-mesenchymal transition estro-siog guidelines androgen-receptor abiraterone acetate lineage plasticity survival analysis growth-factor double-blind progression metastasis |
日期: | 2022 |
上傳時間: | 2023-12-11 14:00:03 (UTC+8) |
出版者: | MDPI |
摘要: | Prostate cancer is featured by its heterogeneous nature, which indicates a different prognosis. Castration-resistant prostate cancer (CRPC) is a hallmark of the treatment-refractory stage, and the median survival of patients is only within two years. Neuroendocrine prostate cancer (NEPC) is an aggressive variant that arises from de novo presentation of small cell carcinoma or treatment-related transformation with a median survival of 1-2 years from the time of diagnosis. The epigenetic regulators, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been proven involved in multiple pathologic mechanisms of CRPC and NEPC. LncRNAs can act as competing endogenous RNAs to sponge miRNAs that would inhibit the expression of their targets. After that, miRNAs interact with the 3' untranslated region (UTR) of target mRNAs to repress the step of translation. These interactions may modulate gene expression and influence cancer development and progression. Otherwise, epigenetic regulators and genetic mutation also promote neuroendocrine differentiation and cancer stem-like cell formation. This step may induce neuroendocrine prostate cancer development. This review aims to provide an integrated, synthesized overview under current evidence to elucidate the crosstalk of lncRNAs with miRNAs and their influence on castration resistance or neuroendocrine differentiation of prostate cancer. Notably, we also discuss the mechanisms of lncRNA-miRNA interaction in androgen receptor-independent prostate cancer, such as growth factors, oncogenic signaling pathways, cell cycle dysregulation, and cytokines or other transmembrane proteins. Conclusively, we underscore the potential of these communications as potential therapeutic targets in the future. |
關聯: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.1, 392 |
顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
|
文件中的檔案:
檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
ijms23010392.pdf | | 1349Kb | Adobe PDF | 109 | 檢視/開啟 | index.html | | 0Kb | HTML | 265 | 檢視/開啟 |
|
在CNU IR中所有的資料項目都受到原著作權保護.
|