Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan's Cancer Registry Database

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標題:	Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan's Cancer Registry Database
作者:	Yu, Shou-Chun Liao, Kuang-Ming Chou, Chia-Lin Tian, Yu-Feng Wang, Jhi-Joung Ho, Chung-Han Shiue, Yow-Ling
貢獻者:	National Sun Yat Sen University Chi Mei Hospital Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Southern Taiwan University of Science & Technology Taipei Medical University Taipei Municipal WanFang Hospital
關鍵字:	charlson comorbidity index colon-cancer prognostic impact risk-adjustment rectal-cancer mortality surgery age quality scores
日期:	2022
上傳時間:	2023-12-11 13:58:07 (UTC+8)
出版者:	SAGE PUBLICATIONS LTD
摘要:	BACKGROUND: Colorectal cancer is one of the leading cancers worldwide. This study aimed to investigate the mortality differences between 2 primary tumor locations, the proximal/distal colon and rectosigmoid junction (RSJ)/rectum. after adjusting for comorbidities. METHODS: The Taiwan Cancer Registry linked with Taiwan's National Health Insurance Research Database was used to estimate the 5-year mortality rate among patients with colorectal cancer. A total of 73769 individuals were enrolled in the study, which included 44234 patients with proximal and distal colon cancers and 29535 patients with RSJ and rectal cancers. Potential mortality risk was calculated using Cox regression analysis. RESULTS: The mortality rates due to the location of the cancer in the proximal/distal colon and RSJ/rectum were 45.27% and 42.20%. respectively. After adjustment for age, sex, comorbidities. and clinical stages, the proximal/distal colon had a 1.03-fold higher 5-year overall mortality rate than RSJ/rectal cancer (95% confidence interval .1.00-1.05). Proximal and distal colon cancers had a worse prognosis and survival than RSJ and rectal colon cancers in women and older patients (>= 70 years). Comorbidities had different effects on mortality in the proximal/distal colon and RSJ/rectum. CONCLUSIONS: Tumor location is associated with the prognosis of patients with colorectal cancer. It is important to treat patients beyond their cancer treatment, and to manage their comorbidities.
關聯:	CLINICAL MEDICINE INSIGHTS-ONCOLOGY, v.16, pp.1-10
顯示於類別:	[保健營養系(所) ] 期刊論文

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