Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34564
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    题名: Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan's Cancer Registry Database
    作者: Yu, Shou-Chun
    Liao, Kuang-Ming
    Chou, Chia-Lin
    Tian, Yu-Feng
    Wang, Jhi-Joung
    Ho, Chung-Han
    Shiue, Yow-Ling
    贡献者: National Sun Yat Sen University
    Chi Mei Hospital
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Southern Taiwan University of Science & Technology
    Taipei Medical University
    Taipei Municipal WanFang Hospital
    关键词: charlson comorbidity index
    colon-cancer
    prognostic impact
    risk-adjustment
    rectal-cancer
    mortality
    surgery
    age
    quality
    scores
    日期: 2022
    上传时间: 2023-12-11 13:58:07 (UTC+8)
    出版者: SAGE PUBLICATIONS LTD
    摘要: BACKGROUND: Colorectal cancer is one of the leading cancers worldwide. This study aimed to investigate the mortality differences between 2 primary tumor locations, the proximal/distal colon and rectosigmoid junction (RSJ)/rectum. after adjusting for comorbidities. METHODS: The Taiwan Cancer Registry linked with Taiwan's National Health Insurance Research Database was used to estimate the 5-year mortality rate among patients with colorectal cancer. A total of 73769 individuals were enrolled in the study, which included 44234 patients with proximal and distal colon cancers and 29535 patients with RSJ and rectal cancers. Potential mortality risk was calculated using Cox regression analysis. RESULTS: The mortality rates due to the location of the cancer in the proximal/distal colon and RSJ/rectum were 45.27% and 42.20%. respectively. After adjustment for age, sex, comorbidities. and clinical stages, the proximal/distal colon had a 1.03-fold higher 5-year overall mortality rate than RSJ/rectal cancer (95% confidence interval .1.00-1.05). Proximal and distal colon cancers had a worse prognosis and survival than RSJ and rectal colon cancers in women and older patients (>= 70 years). Comorbidities had different effects on mortality in the proximal/distal colon and RSJ/rectum. CONCLUSIONS: Tumor location is associated with the prognosis of patients with colorectal cancer. It is important to treat patients beyond their cancer treatment, and to manage their comorbidities.
    關聯: CLINICAL MEDICINE INSIGHTS-ONCOLOGY, v.16, pp.1-10
    显示于类别:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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