Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/34534
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    標題: Clinical Outcomes and Adverse Effects in Septic Patients with Impaired Renal Function Who Received Different Dosages of Cefoperazone-Sulbactam
    作者: Tai, Chien-Hsiang
    Tang, Hung-Jen
    Lee, Chen-Hsiang
    貢獻者: Chang Gung Memorial Hospital
    Chi Mei Hospital
    Chi Mei Hospital
    Department of Health and Nutrition, Chia Nan University of Pharmacy & Science
    Chang Gung University
    關鍵字: resistant
    therapy
    pharmacokinetics
    pneumonia
    efficacy
    日期: 2022
    上傳時間: 2023-12-11 13:56:31 (UTC+8)
    出版者: MDPI
    摘要: This study aimed to compare clinical outcomes and adverse effects in septic patients with impaired renal function who received different dosages of cefoperazone-sulbactam (CFP-SUL 1 g/1 g or 2 g/2 g every 12 h). The retrospective study was conducted using the Chang Gung Research Database to include adult patients who had renal insufficiency presented with septicemia caused by Gram-negative organisms and had received CFP-SUL for more than 1 week. A total of 265 patients (44 in the CFP-SUL 1 g/1 g group and 221 in the CFP-SUL 2 g/2 g group) were eligible to be included in this study. After 1:3 propensity score matching, 41 and 123 patients in the CFP-SUL 1 g/1 g and CFP-SUL 2 g/2 g groups, respectively, were included for analyses. There were no significant between-group differences in all-cause mortality rates and adverse effects, including prolonged prothrombin time. A logistic regression model showed that the Pitt bacteremia score was related to all-cause mortality rate and prolonged prothrombin time was associated with renal replacement therapy. The adverse effects of CFP-SUL did not increase in septic patients with impaired renal function receiving CFP-SUL 2 g/2 g Q12H. However, this study may be underpowered to reveal a difference in all-cause mortality.
    關聯: Antibiotics-Basel, v.11, n.4, pp.460
    显示于类别:[保健營養系(所) ] 期刊論文

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