Clinical Outcomes and Adverse Effects in Septic Patients with Impaired Renal Function Who Received Different Dosages of Cefoperazone-Sulbactam

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Title:	Clinical Outcomes and Adverse Effects in Septic Patients with Impaired Renal Function Who Received Different Dosages of Cefoperazone-Sulbactam
Authors:	Tai, Chien-Hsiang Tang, Hung-Jen Lee, Chen-Hsiang
Contributors:	Chang Gung Memorial Hospital Chi Mei Hospital Chi Mei Hospital Department of Health and Nutrition, Chia Nan University of Pharmacy & Science Chang Gung University
Keywords:	resistant therapy pharmacokinetics pneumonia efficacy
Date:	2022
Issue Date:	2023-12-11 13:56:31 (UTC+8)
Publisher:	MDPI
Abstract:	This study aimed to compare clinical outcomes and adverse effects in septic patients with impaired renal function who received different dosages of cefoperazone-sulbactam (CFP-SUL 1 g/1 g or 2 g/2 g every 12 h). The retrospective study was conducted using the Chang Gung Research Database to include adult patients who had renal insufficiency presented with septicemia caused by Gram-negative organisms and had received CFP-SUL for more than 1 week. A total of 265 patients (44 in the CFP-SUL 1 g/1 g group and 221 in the CFP-SUL 2 g/2 g group) were eligible to be included in this study. After 1:3 propensity score matching, 41 and 123 patients in the CFP-SUL 1 g/1 g and CFP-SUL 2 g/2 g groups, respectively, were included for analyses. There were no significant between-group differences in all-cause mortality rates and adverse effects, including prolonged prothrombin time. A logistic regression model showed that the Pitt bacteremia score was related to all-cause mortality rate and prolonged prothrombin time was associated with renal replacement therapy. The adverse effects of CFP-SUL did not increase in septic patients with impaired renal function receiving CFP-SUL 2 g/2 g Q12H. However, this study may be underpowered to reveal a difference in all-cause mortality.
Relation:	Antibiotics-Basel, v.11, n.4, pp.460
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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