 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 18269/20496 (89%)
Visitors : 10049024
Online Users : 888
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://ir.cnu.edu.tw/handle/310902800/34528
|
標題: | miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts |
作者: | Chang, Wei-Ting Shih, Jhih-Yuan Lin, Yu-Wen Huang, Tzu-Ling Chen, Zhih-Cherng Chen, Chi-Long Chu, Jan-Show Liu, Ping Yen |
貢獻者: | National Cheng Kung University Chi Mei Hospital Southern Taiwan University of Science & Technology Chia Nan University of Pharmacy & Science, Department of Health and Nutrition Taipei Medical University Taipei Medical University Hospital Taipei Medical University National Cheng Kung University National Cheng Kung University Hospital |
關鍵字: | blood-pressure micrornas failure progression management roles |
日期: | 2022 |
上傳時間: | 2023-12-11 13:55:55 (UTC+8) |
出版者: | IMPACT JOURNALS LLC |
摘要: | Young and aging hearts undergo different remodeling post pressure overload, but the regulator that determines responses to pressure overload at different ages remains unknown. With an angiotensin II (Ang II)-induced hypertensive model, miR-21 knockout mice (miR-21(-/-)) were observed regarding the effects of miR-21 on hypertension-induced cardiac remodeling in young (12 week-old) and old (50 week-old) mice. Although the aged heart represented a more significant hypertrophy and was associated with a higher expression of miR-21, Ang II-induced cardiac hypertrophy was attenuated in miR-21(-/-) mice. Upon results of cardiac-specific arrays in miR-21-overexpressing cardiomyocytes, we found a significant downregulation of S100a8. In both in vitro and in vivo models, miR-21/S100a8/NF-kappa B/NFAT pathway was observed to be associated with pressure overload-induced hypertrophic remodeling in aged hearts. To further investigate whether circulating miR-21 could be a biomarker reflecting the aged associated cardiac remodeling, we prospectively collected clinical and echocardiographic information of patients at young (<65 y/o) and old ages (>= 65 y/o) with and without hypertension. Among 108 patients, aged subjects presented with a significantly higher expression of circulating miR-21, which was positively correlated with left ventricular wall thickness. Collectively, miR-21 was associated with a prominently hypertrophic response in aged hearts under pressure overload. Further studies should focus on therapeutic potentials of miR-21. |
關聯: | AGING-US, v.14, Issue 14, pp.CC2, pp.5925—5945 |
Appears in Collections: | [保健營養系(所) ] 期刊論文
|
Files in This Item:
File |
Description |
Size | Format | |
35907209.pdf | | 2039Kb | Adobe PDF | 106 | View/Open | index.html | | 0Kb | HTML | 385 | View/Open |
|
All items in CNU IR are protected by copyright, with all rights reserved.
|