miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

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Title:	miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts
Authors:	Chang, Wei-Ting Shih, Jhih-Yuan Lin, Yu-Wen Huang, Tzu-Ling Chen, Zhih-Cherng Chen, Chi-Long Chu, Jan-Show Liu, Ping Yen
Contributors:	National Cheng Kung University Chi Mei Hospital Southern Taiwan University of Science & Technology Chia Nan University of Pharmacy & Science, Department of Health and Nutrition Taipei Medical University Taipei Medical University Hospital Taipei Medical University National Cheng Kung University National Cheng Kung University Hospital
Keywords:	blood-pressure micrornas failure progression management roles
Date:	2022
Issue Date:	2023-12-11 13:55:55 (UTC+8)
Publisher:	IMPACT JOURNALS LLC
Abstract:	Young and aging hearts undergo different remodeling post pressure overload, but the regulator that determines responses to pressure overload at different ages remains unknown. With an angiotensin II (Ang II)-induced hypertensive model, miR-21 knockout mice (miR-21(-/-)) were observed regarding the effects of miR-21 on hypertension-induced cardiac remodeling in young (12 week-old) and old (50 week-old) mice. Although the aged heart represented a more significant hypertrophy and was associated with a higher expression of miR-21, Ang II-induced cardiac hypertrophy was attenuated in miR-21(-/-) mice. Upon results of cardiac-specific arrays in miR-21-overexpressing cardiomyocytes, we found a significant downregulation of S100a8. In both in vitro and in vivo models, miR-21/S100a8/NF-kappa B/NFAT pathway was observed to be associated with pressure overload-induced hypertrophic remodeling in aged hearts. To further investigate whether circulating miR-21 could be a biomarker reflecting the aged associated cardiac remodeling, we prospectively collected clinical and echocardiographic information of patients at young (<65 y/o) and old ages (>= 65 y/o) with and without hypertension. Among 108 patients, aged subjects presented with a significantly higher expression of circulating miR-21, which was positively correlated with left ventricular wall thickness. Collectively, miR-21 was associated with a prominently hypertrophic response in aged hearts under pressure overload. Further studies should focus on therapeutic potentials of miR-21.
Relation:	AGING-US, v.14, Issue 14, pp.CC2, pp.5925—5945
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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