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| 標題: | Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging |
| 作者: | Poomanee, Worrapan
Khunkitti, Watcharee
Chaiyana, Wantida
Intasai, Nutjeera
Lin, Wei-Chao
Lue, Shang-Chian
Leelapornpisid, Pimporn |
| 貢獻者: | Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Sci
Khon Kaen Univ, Fac Pharmaceut Sci
Chiang Mai Univ, Fac Pharm, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut
Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Div Clin Microscopy
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci |
| 關鍵字: | Mangifera indica L. kernel
Matrix metalloproteinases
Anti-tyrosinase
Anti-hyaluronidase
Anti-inflammatory
DNA damage |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:56:08 (UTC+8) |
| 出版者: | KOREAN SOC TOXICOLOGY |
| 摘要: | This study aimed to investigate the potential of Mangifera indica L. seed kernel extract, which is highly discarded by the global food processing industry, as a multifunctional bioactive ingredient for nutraceutical and cosmeceutical applications. Different extracting solvents were utilized, the extracts were then tested for their antioxidant activities using DPPH, ABTS radical scavenging assays, and inhibition of lipid peroxidation. Additionally, total phenolic content (TPC), total flavonoid content (TFC), and gallic acid content were elucidated using Folin-Ciocalteu and aluminum chloride colorimetric assays, as well as high performance liquid chromatography. The hydroethanolic extract (KMHE) exhibited the highest percentage yield, with the highest antioxidant activity owing to its high phenolic content. KMHE consisted of 773.66 +/- 9.42 mg GAE/g extract in TPC, 36.20 +/- 4.20 mg RU/g extract in TFC. Additionally, gallic acid was shown to be a major constituent of KMHE. KMHE was investigated for anti-tyrosinase, anti-hyaluronidase, anti-MMP-2, and anti-MMP-9 activities. Moreover, the anti-inflammatory effects of KMHE were studied in RAW 264.7 cells induced by nitric oxide and KMHE was shown to prevent DNA damage, indicating an inhibitory effect on cellular aging. KMHE showed outstanding anti-tyrosinase activity and was as potent an anti-hyaluronidase as gallic acid. Additionally, our results reveal notable anti-MMP-2 and anti-MMP-9 effects that were not significantly different from those of gallic acid. Furthermore, KMHE demonstrated 61.54 +/- 2.39% nitric oxide inhibition, with no cytotoxic effects, in RAW264.7 cells, and also prevented DNA damage in the human fibroblast BJ cell line with no cytotoxic effects. Therefore, KMHE could be a promising, natural multifunctional bioactive compound for nutraceutical and cosmeceutical applications. |
| 關聯: | TOXICOL RES-GER, v.37, n.4, pp.459-472 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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