Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging

doi:10.1007/s43188-020-00079-6

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/34474

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標題:	Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging
作者:	Poomanee, Worrapan Khunkitti, Watcharee Chaiyana, Wantida Intasai, Nutjeera Lin, Wei-Chao Lue, Shang-Chian Leelapornpisid, Pimporn
貢獻者:	Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Sci Khon Kaen Univ, Fac Pharmaceut Sci Chiang Mai Univ, Fac Pharm, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Div Clin Microscopy Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci
關鍵字:	Mangifera indica L. kernel Matrix metalloproteinases Anti-tyrosinase Anti-hyaluronidase Anti-inflammatory DNA damage
日期:	2021
上傳時間:	2023-11-11 11:56:08 (UTC+8)
出版者:	KOREAN SOC TOXICOLOGY
摘要:	This study aimed to investigate the potential of Mangifera indica L. seed kernel extract, which is highly discarded by the global food processing industry, as a multifunctional bioactive ingredient for nutraceutical and cosmeceutical applications. Different extracting solvents were utilized, the extracts were then tested for their antioxidant activities using DPPH, ABTS radical scavenging assays, and inhibition of lipid peroxidation. Additionally, total phenolic content (TPC), total flavonoid content (TFC), and gallic acid content were elucidated using Folin-Ciocalteu and aluminum chloride colorimetric assays, as well as high performance liquid chromatography. The hydroethanolic extract (KMHE) exhibited the highest percentage yield, with the highest antioxidant activity owing to its high phenolic content. KMHE consisted of 773.66 +/- 9.42 mg GAE/g extract in TPC, 36.20 +/- 4.20 mg RU/g extract in TFC. Additionally, gallic acid was shown to be a major constituent of KMHE. KMHE was investigated for anti-tyrosinase, anti-hyaluronidase, anti-MMP-2, and anti-MMP-9 activities. Moreover, the anti-inflammatory effects of KMHE were studied in RAW 264.7 cells induced by nitric oxide and KMHE was shown to prevent DNA damage, indicating an inhibitory effect on cellular aging. KMHE showed outstanding anti-tyrosinase activity and was as potent an anti-hyaluronidase as gallic acid. Additionally, our results reveal notable anti-MMP-2 and anti-MMP-9 effects that were not significantly different from those of gallic acid. Furthermore, KMHE demonstrated 61.54 +/- 2.39% nitric oxide inhibition, with no cytotoxic effects, in RAW264.7 cells, and also prevented DNA damage in the human fibroblast BJ cell line with no cytotoxic effects. Therefore, KMHE could be a promising, natural multifunctional bioactive compound for nutraceutical and cosmeceutical applications.
關聯:	TOXICOL RES-GER, v.37, n.4, pp.459-472
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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