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標題: | Production of a new triterpenoid disaccharide saponin from sequential glycosylation of ganoderic acid A by 2 Bacillus glycosyltransferases |
作者: | Chang, Te-Sheng Chiang, Chien-Min Wu, Jiumn-Yih Tsai, Yu-Li Ting, Huei-Ju |
貢獻者: | Natl Univ Tainan, Dept Biol Sci & Technol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Quemoy Univ, Dept Food Sci |
關鍵字: | ganoderic acid A glycosyltransferase triterpenoid glucosides saponin |
日期: | 2021 |
上傳時間: | 2023-11-11 11:55:41 (UTC+8) |
出版者: | OXFORD UNIV PRESS |
摘要: | Ganoderic acid A (GAA) is a lanostane-type triterpenoid, isolated from medicinal fungus Ganoderma lucidum, and possesses multiple bioactivities. In the present study, GAA was sequentially biotransformed by 2 recently discovered Bacillus glycosyltransferases (GT), BtGT_16345 and BsGT110, and the final product was purified and identified as a new compound, GAA-15,26-O-beta-diglucoside, which showed 1024-fold aqueous solubility than GAA. |
關聯: | BIOSCI BIOTECH BIOCH, v.85, n.3, pp.687-690 |
顯示於類別: | [藥學系(所)] 期刊論文
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