Production of a new triterpenoid disaccharide saponin from sequential glycosylation of ganoderic acid A by 2 Bacillus glycosyltransferases

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Title:	Production of a new triterpenoid disaccharide saponin from sequential glycosylation of ganoderic acid A by 2 Bacillus glycosyltransferases
Authors:	Chang, Te-Sheng Chiang, Chien-Min Wu, Jiumn-Yih Tsai, Yu-Li Ting, Huei-Ju
Contributors:	Natl Univ Tainan, Dept Biol Sci & Technol Chia Nan Univ Pharm & Sci, Dept Pharm Natl Quemoy Univ, Dept Food Sci
Keywords:	ganoderic acid A glycosyltransferase triterpenoid glucosides saponin
Date:	2021
Issue Date:	2023-11-11 11:55:41 (UTC+8)
Publisher:	OXFORD UNIV PRESS
Abstract:	Ganoderic acid A (GAA) is a lanostane-type triterpenoid, isolated from medicinal fungus Ganoderma lucidum, and possesses multiple bioactivities. In the present study, GAA was sequentially biotransformed by 2 recently discovered Bacillus glycosyltransferases (GT), BtGT_16345 and BsGT110, and the final product was purified and identified as a new compound, GAA-15,26-O-beta-diglucoside, which showed 1024-fold aqueous solubility than GAA.
Relation:	BIOSCI BIOTECH BIOCH, v.85, n.3, pp.687-690
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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