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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34469

    標題: CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer
    作者: Chen, Pin-Shern
    Hsu, Hui-Ping
    Phan, Nam Nhut
    Yen, Meng-Chi
    Chen, Feng-Wei
    Liu, Yu-Wei
    Lin, Fang-Ping
    Feng, Sheng-Yao
    Cheng, Tsung-Lin
    Yeh, Pei-Hsiang
    Omar, Hany A.
    Sun, Zhengda
    Jiang, Jia-Zhen
    Chan, Yi-Shin
    Lai, Ming-Derg
    Wang, Chih-Yang
    Hung, Jui-Hsiang
    貢獻者: Chia Nan Univ Pharm & Sci, Dept Biotechnol
    Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg
    Nguyen Tat Thanh Univ, NTT Inst Hitechnol
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Emergency Med
    Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med
    Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Dept Biochem & Mol Biol
    Kaohsiung Med Univ, Coll Med, Sch Med, Dept Physiol
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Orthoped Res Ctr
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res
    Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr
    Univ Sharjah, Sharjah Inst Med Res
    Univ Sharjah, Coll Pharm
    Ajman Univ, Coll Pharm, Dept Clin Sci
    BeniSuef Univ, Fac Pharm, Dept Pharmacol, Bani Suwayf 62511, Egypt;[Sun, Zhengda
    Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp
    Fudan Univ, Huashan Hosp North, Emergency Dept
    Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery
    Taipei Med Univ, Coll Med Sci & Technol, PhD Program Canc Mol Biol & Drug Discovery
    關鍵字: coiled-coil domain-containing protein 167
    breast cancer
    cell proliferation
    cell growth
    日期: 2021
    上傳時間: 2023-11-11 11:55:38 (UTC+8)
    摘要: According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast cancers are grouped as ER-positive, which implies a crucial role for estrogen in breast cancer development. Therefore, identifying potential therapeutic targets and investigating their downstream pathways and networks are extremely important for drug development in these patients. Through high-throughput technology and bioinformatics screening, we revealed that coiled-coil domain-containing protein 167 (CCDC167) was upregulated in different types of tumors; however, the role of CCDC167 in the development of breast cancer still remains unclear. Integrating many kinds of databases including ONCOMINE, MetaCore, IPA, and KaplanMeier Plotter, we found that high expression levels of CCDC167 predicted poor prognoses of breast cancer patients. Knockdown of CCDC167 attenuated aggressive breast cancer growth and proliferation. We also demonstrated that treatment with fluorouracil, carboplatin, paclitaxel, and doxorubicin resulted in decreased expression of CCDC167 and suppressed growth of MCF-7 cells. Collectively, these findings suggest that CCDC167 has high potential as a therapeutic target for breast cancer.
    關聯: AGING-US, v.13, n.3, pp.4157-4181
    Appears in Collections:[生物科技系(所)] 期刊論文

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