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| 標題: | CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer |
| 作者: | Chen, Pin-Shern
Hsu, Hui-Ping
Phan, Nam Nhut
Yen, Meng-Chi
Chen, Feng-Wei
Liu, Yu-Wei
Lin, Fang-Ping
Feng, Sheng-Yao
Cheng, Tsung-Lin
Yeh, Pei-Hsiang
Omar, Hany A.
Sun, Zhengda
Jiang, Jia-Zhen
Chan, Yi-Shin
Lai, Ming-Derg
Wang, Chih-Yang
Hung, Jui-Hsiang |
| 貢獻者: | Chia Nan Univ Pharm & Sci, Dept Biotechnol
Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg
Nguyen Tat Thanh Univ, NTT Inst Hitechnol
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Emergency Med
Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med
Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Dept Biochem & Mol Biol
Kaohsiung Med Univ, Coll Med, Sch Med, Dept Physiol
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Orthoped Res Ctr
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res
Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr
Univ Sharjah, Sharjah Inst Med Res
Univ Sharjah, Coll Pharm
Ajman Univ, Coll Pharm, Dept Clin Sci
BeniSuef Univ, Fac Pharm, Dept Pharmacol, Bani Suwayf 62511, Egypt;[Sun, Zhengda
Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp
Fudan Univ, Huashan Hosp North, Emergency Dept
Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery
Taipei Med Univ, Coll Med Sci & Technol, PhD Program Canc Mol Biol & Drug Discovery |
| 關鍵字: | coiled-coil domain-containing protein 167
breast cancer
cell proliferation
cell growth
bioinformatics |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:55:38 (UTC+8) |
| 出版者: | IMPACT JOURNALS LLC |
| 摘要: | According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast cancers are grouped as ER-positive, which implies a crucial role for estrogen in breast cancer development. Therefore, identifying potential therapeutic targets and investigating their downstream pathways and networks are extremely important for drug development in these patients. Through high-throughput technology and bioinformatics screening, we revealed that coiled-coil domain-containing protein 167 (CCDC167) was upregulated in different types of tumors; however, the role of CCDC167 in the development of breast cancer still remains unclear. Integrating many kinds of databases including ONCOMINE, MetaCore, IPA, and KaplanMeier Plotter, we found that high expression levels of CCDC167 predicted poor prognoses of breast cancer patients. Knockdown of CCDC167 attenuated aggressive breast cancer growth and proliferation. We also demonstrated that treatment with fluorouracil, carboplatin, paclitaxel, and doxorubicin resulted in decreased expression of CCDC167 and suppressed growth of MCF-7 cells. Collectively, these findings suggest that CCDC167 has high potential as a therapeutic target for breast cancer. |
| 關聯: | AGING-US, v.13, n.3, pp.4157-4181 |
| 顯示於類別: | [生物科技系(所)] 期刊論文
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