CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer

doi:10.18632/aging.202382

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 生物科技系(所) > 期刊論文 > Item 310902800/34469

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標題:	CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer
作者:	Chen, Pin-Shern Hsu, Hui-Ping Phan, Nam Nhut Yen, Meng-Chi Chen, Feng-Wei Liu, Yu-Wei Lin, Fang-Ping Feng, Sheng-Yao Cheng, Tsung-Lin Yeh, Pei-Hsiang Omar, Hany A. Sun, Zhengda Jiang, Jia-Zhen Chan, Yi-Shin Lai, Ming-Derg Wang, Chih-Yang Hung, Jui-Hsiang
貢獻者:	Chia Nan Univ Pharm & Sci, Dept Biotechnol Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg Nguyen Tat Thanh Univ, NTT Inst Hitechnol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Emergency Med Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Dept Biochem & Mol Biol Kaohsiung Med Univ, Coll Med, Sch Med, Dept Physiol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Orthoped Res Ctr Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr Univ Sharjah, Sharjah Inst Med Res Univ Sharjah, Coll Pharm Ajman Univ, Coll Pharm, Dept Clin Sci BeniSuef Univ, Fac Pharm, Dept Pharmacol, Bani Suwayf 62511, Egypt;[Sun, Zhengda Kaiser Permanente, Northern Calif Reg Labs, Permanente Med Grp Fudan Univ, Huashan Hosp North, Emergency Dept Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery Taipei Med Univ, Coll Med Sci & Technol, PhD Program Canc Mol Biol & Drug Discovery
關鍵字:	coiled-coil domain-containing protein 167 breast cancer cell proliferation cell growth bioinformatics
日期:	2021
上傳時間:	2023-11-11 11:55:38 (UTC+8)
出版者:	IMPACT JOURNALS LLC
摘要:	According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast cancers are grouped as ER-positive, which implies a crucial role for estrogen in breast cancer development. Therefore, identifying potential therapeutic targets and investigating their downstream pathways and networks are extremely important for drug development in these patients. Through high-throughput technology and bioinformatics screening, we revealed that coiled-coil domain-containing protein 167 (CCDC167) was upregulated in different types of tumors; however, the role of CCDC167 in the development of breast cancer still remains unclear. Integrating many kinds of databases including ONCOMINE, MetaCore, IPA, and KaplanMeier Plotter, we found that high expression levels of CCDC167 predicted poor prognoses of breast cancer patients. Knockdown of CCDC167 attenuated aggressive breast cancer growth and proliferation. We also demonstrated that treatment with fluorouracil, carboplatin, paclitaxel, and doxorubicin resulted in decreased expression of CCDC167 and suppressed growth of MCF-7 cells. Collectively, these findings suggest that CCDC167 has high potential as a therapeutic target for breast cancer.
關聯:	AGING-US, v.13, n.3, pp.4157-4181
显示于类别:	[生物科技系(所)] 期刊論文

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