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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34453


    標題: Malignant transformation of oral potentially malignant disorders in Taiwan An observational nationwide population database study
    作者: Chiu, Sheng-Fu
    Ho, Chung-Han
    Chen, Yi-Chen
    Wu, Li-Wha
    Chen, Yuh-Ling
    Wu, Jer-Horng
    Wu, Wei-Sheng
    Hung, Hui-Kun
    Chiang, Wei-Fan
    貢獻者: Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg
    Chi Mei Med Ctr, Dept Med Res
    Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
    Natl Cheng Kung Univ, Coll Med, Inst Mol Med
    Kaohsiung Med Univ, Coll Hlth Sci, Dept Lab Sci & Technol
    Natl Cheng Kung Univ, Coll Med, Inst Oral Med
    Natl Cheng Kung Univ, Dept Environm Engn
    Natl Cheng Kung Univ, Dept Elect Engn
    Chi Mei Med Ctr, Dept Plast Surg
    Natl Yang Ming Univ, Sch Dent
    關鍵字: betel nut
    erythroplakia
    leukoplakia
    malignant transformation
    oral cancer
    oral lichen planus
    oral mucosal screening
    oral potentially malignant disorders
    oral submucosal fibrosis
    oral verrucous hyperplasia
    日期: 2021
    上傳時間: 2023-11-11 11:53:38 (UTC+8)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    摘要: Oral cancer is one of the leading causes of cancer death, which are mostly preceded by oral potentially malignant disorders (OPMDs). Taiwanese government launched a free oral cancer screening program. The aim of this study was to analyze the malignant transformation rate of OPMDs. This study was based on national-wide oral screening databases. 3,362,232 people were enrolled. Patients clinically diagnosed with leukoplakia, erythroplakia, oral submucosal fibrosis (OSF), oral verrucous hyperplasia (OVH), and oral lichen planus (OLP), from 2010 to 2013, were identified. We followed up OPMD patients in cancer registry databases to analyze the malignant transformation rate. The malignant transformation rates from the highest to the lowest were: OVH > OSF > erythroplakia > OLP > leukoplakia. The malignant transformation rate was 24.55, 12.76, 9.75, 4.23, and 0.60 per 1000 person-years in the OVH, OSF, erythroplakia, leukoplakia, and comparison cohort. The hazard ratio was 8.19 times higher in the OPMD group compared with comparison cohort group, after age and habit adjustment. Female patients with OPMDs had a high risk of malignant transformation. Nationwide screening is very important for early diagnosis. OVH had the highest malignant transformation possibility. Female OPMD patients are a rare but have a relatively high malignant transformation rate.
    關聯: MEDICINE, v.100, n.9, e24934
    Appears in Collections:[醫務管理系(所)] 期刊論文

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