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| 標題: | Malignant transformation of oral potentially malignant disorders in Taiwan An observational nationwide population database study |
| 作者: | Chiu, Sheng-Fu
Ho, Chung-Han
Chen, Yi-Chen
Wu, Li-Wha
Chen, Yuh-Ling
Wu, Jer-Horng
Wu, Wei-Sheng
Hung, Hui-Kun
Chiang, Wei-Fan |
| 貢獻者: | Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg
Chi Mei Med Ctr, Dept Med Res
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Natl Cheng Kung Univ, Coll Med, Inst Mol Med
Kaohsiung Med Univ, Coll Hlth Sci, Dept Lab Sci & Technol
Natl Cheng Kung Univ, Coll Med, Inst Oral Med
Natl Cheng Kung Univ, Dept Environm Engn
Natl Cheng Kung Univ, Dept Elect Engn
Chi Mei Med Ctr, Dept Plast Surg
Natl Yang Ming Univ, Sch Dent |
| 關鍵字: | betel nut
erythroplakia
leukoplakia
malignant transformation
oral cancer
oral lichen planus
oral mucosal screening
oral potentially malignant disorders
oral submucosal fibrosis
oral verrucous hyperplasia |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:53:38 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Oral cancer is one of the leading causes of cancer death, which are mostly preceded by oral potentially malignant disorders (OPMDs). Taiwanese government launched a free oral cancer screening program. The aim of this study was to analyze the malignant transformation rate of OPMDs. This study was based on national-wide oral screening databases. 3,362,232 people were enrolled. Patients clinically diagnosed with leukoplakia, erythroplakia, oral submucosal fibrosis (OSF), oral verrucous hyperplasia (OVH), and oral lichen planus (OLP), from 2010 to 2013, were identified. We followed up OPMD patients in cancer registry databases to analyze the malignant transformation rate. The malignant transformation rates from the highest to the lowest were: OVH > OSF > erythroplakia > OLP > leukoplakia. The malignant transformation rate was 24.55, 12.76, 9.75, 4.23, and 0.60 per 1000 person-years in the OVH, OSF, erythroplakia, leukoplakia, and comparison cohort. The hazard ratio was 8.19 times higher in the OPMD group compared with comparison cohort group, after age and habit adjustment. Female patients with OPMDs had a high risk of malignant transformation. Nationwide screening is very important for early diagnosis. OVH had the highest malignant transformation possibility. Female OPMD patients are a rare but have a relatively high malignant transformation rate. |
| 關聯: | MEDICINE, v.100, n.9, e24934 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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