Malignant transformation of oral potentially malignant disorders in Taiwan An observational nationwide population database study

doi:10.1097/MD.0000000000024934

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題名:	Malignant transformation of oral potentially malignant disorders in Taiwan An observational nationwide population database study
作者:	Chiu, Sheng-Fu Ho, Chung-Han Chen, Yi-Chen Wu, Li-Wha Chen, Yuh-Ling Wu, Jer-Horng Wu, Wei-Sheng Hung, Hui-Kun Chiang, Wei-Fan
貢獻者:	Chi Mei Med Ctr, Dept Oral & Maxillofacial Surg Chi Mei Med Ctr, Dept Med Res Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Natl Cheng Kung Univ, Coll Med, Inst Mol Med Kaohsiung Med Univ, Coll Hlth Sci, Dept Lab Sci & Technol Natl Cheng Kung Univ, Coll Med, Inst Oral Med Natl Cheng Kung Univ, Dept Environm Engn Natl Cheng Kung Univ, Dept Elect Engn Chi Mei Med Ctr, Dept Plast Surg Natl Yang Ming Univ, Sch Dent
關鍵詞:	betel nut erythroplakia leukoplakia malignant transformation oral cancer oral lichen planus oral mucosal screening oral potentially malignant disorders oral submucosal fibrosis oral verrucous hyperplasia
日期:	2021
上傳時間:	2023-11-11 11:53:38 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	Oral cancer is one of the leading causes of cancer death, which are mostly preceded by oral potentially malignant disorders (OPMDs). Taiwanese government launched a free oral cancer screening program. The aim of this study was to analyze the malignant transformation rate of OPMDs. This study was based on national-wide oral screening databases. 3,362,232 people were enrolled. Patients clinically diagnosed with leukoplakia, erythroplakia, oral submucosal fibrosis (OSF), oral verrucous hyperplasia (OVH), and oral lichen planus (OLP), from 2010 to 2013, were identified. We followed up OPMD patients in cancer registry databases to analyze the malignant transformation rate. The malignant transformation rates from the highest to the lowest were: OVH > OSF > erythroplakia > OLP > leukoplakia. The malignant transformation rate was 24.55, 12.76, 9.75, 4.23, and 0.60 per 1000 person-years in the OVH, OSF, erythroplakia, leukoplakia, and comparison cohort. The hazard ratio was 8.19 times higher in the OPMD group compared with comparison cohort group, after age and habit adjustment. Female patients with OPMDs had a high risk of malignant transformation. Nationwide screening is very important for early diagnosis. OVH had the highest malignant transformation possibility. Female OPMD patients are a rare but have a relatively high malignant transformation rate.
關聯:	MEDICINE, v.100, n.9, e24934
顯示於類別:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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