Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience

doi:10.1186/s13058-021-01421-y

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/34449

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標題:	Sole adjuvant intraoperative breast radiotherapy in Taiwan: a single-center experience
作者:	Yang, Hsin-Yi Tu, Chi-Wen Chen, Chien-Chin Lee, Cheng-Yen Hsu, Yu-Chen
貢獻者:	Ditmans Med Fdn, Clin Med Res Ctr, Chia Yi Christian Hosp Ditmans Med Fdn, Clin Med Res Ctr, Chia Yi Christian Hosp, Dept Surg Ditmanson Med Fdn, Chia Yi Christian Hosp, Dept Pathol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Ditmanson Med Fdn, Chia Yi Christian Hosp, Dept Radiat Therapy & Oncol
關鍵字:	Breast cancer Intraoperative radiotherapy Whole breast external beam radiotherapy
日期:	2021
上傳時間:	2023-11-11 11:53:24 (UTC+8)
出版者:	BMC
摘要:	Introduction Intraoperative radiotherapy (IORT) is more convenient than standard whole breast external beam radiotherapy (EBRT) as a sole adjuvant radiotherapy for breast cancer. The impact of age on breast cancer course and treatment strategy is still under investigation, and the peak age for breast cancer in Taiwan is much younger than that in Western countries. We aimed to review the oncological outcomes of sole IORT compared with standard EBRT in a country with younger breast cancer patients. Patients and methods We reviewed patients with invasive breast cancer who received breast-conserving surgery (BCS) from September 2014 to December 2016. The clinicopathologic characteristics and oncological outcomes of eligible patients who received EBRT or IORT as sole adjuvant radiotherapy after BCS were collected and reviewed. Results A total of 170 patients were enrolled with a mean follow-up time of 3.53 +/- 0.82 years. The risk of locoregional recurrence was 2.44% for EBRT versus 10.64% for IORT (p = 0.024). IORT was a significant risk factor of locoregional recurrence (p = 0.005). The hazard ratios (HRs) for locoregional recurrence in the IORT group compared with the EBRT group were significantly higher in non-suitable risk group patients (HR = 7.02, p = 0.009) and in patients under 50 years old (HR = 10.42, p = 0.011). Conclusions Locoregional recurrence was significantly higher in patients who received IORT than in those who underwent EBRT. IORT should not be used alone in patients under 50 years old who do not belong to a suitable group.
關聯:	BREAST CANCER RES, v.23, n.1, pp.43
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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