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https://ir.cnu.edu.tw/handle/310902800/34437
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| 標題: | Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study |
| 作者: | Hu, Je-Ming
Wu, Jia-Jheng
Hsu, Chih-Hsiung
Chen, Yong-Chen
Tian, Yu-Feng
Chang, Pi-Kai
Chen, Chao-Yang
Chou, Yu-Ching
Sun, Chien-An |
| 貢獻者: | Natl Def Med Ctr, Grad Inst Med Sci
Triserv Gen Hosp, Div Colorectal Surg, Dept Surg, Natl Def Med Ctr
Natl Def Med Ctr, Sch Publ Hlth
Triserv Gen Hosp, Teaching Off, Natl Def Med Ctr
Fu Jen Catholic Univ, Dept Med, Coll Med
Fu Jen Catholic Univ, Big Data Res Ctr, Coll Med
Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg
Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
Fu Jen Catholic Univ, Dept Publ Hlth, Coll Med |
| 關鍵字: | Colorectal cancer
Gastroesophageal reflux disease
National Health Insurance Research Database
Retrospective cohort study |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:52:41 (UTC+8) |
| 出版者: | SPRINGER |
| 摘要: | Purpose Several studies have investigated the association between gastroesophageal reflux disease (GERD) and colorectal cancer (CRC) risk, but the presented scientific results are highly debatable. This study examined the longitudinal association between GERD and CRC in an Asian population. Methods A retrospective cohort study was performed using the National Health Insurance Research Database of Taiwan. The study cohort comprised 45,828 individuals with newly diagnosed GERD (the GERD cohort) and 229,140 age, sex, and date of enrollment-matched patients without GERD (the comparison cohort) from 2000 to 2006. The primary outcome was the incidence of CRC. To estimate the effect of GERD on the risk of CRC, the Cox proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results There were 785 newly diagnosed CRC patients in the 45,828 patients with GERD. Relatively, there were 2375 incident CRC cases in 229,140 patients without GERD. The incidence rate of CRC for the GERD cohort (17.60 per 10,000 person-years) was significantly higher than the corresponding incidence rate for the comparison cohort (10.22 per 10,000 person-years). After adjustment for confounders, GERD was associated with a significantly increased risk of CRC (adjusted HR,1.76; 95% CI, 1.62-2.90). Of note, a significant association between GERD and CRC risk was evident in both genders. Conclusions In conclusion, this nationwide population-based cohort study supports the hypothesis that GERD was associated with a significantly increased risk of CRC. Our findings warrant still further investigation of the underlying mechanisms related to carcinogenic effect of GERD on colorectal carcinoma. |
| 關聯: | INT J COLORECTAL DIS, v.36, n.11, pp.2411-2418 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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