Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study

doi:10.1007/s00384-021-03873-2

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/34437

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34437

Title:	Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study
Authors:	Hu, Je-Ming Wu, Jia-Jheng Hsu, Chih-Hsiung Chen, Yong-Chen Tian, Yu-Feng Chang, Pi-Kai Chen, Chao-Yang Chou, Yu-Ching Sun, Chien-An
Contributors:	Natl Def Med Ctr, Grad Inst Med Sci Triserv Gen Hosp, Div Colorectal Surg, Dept Surg, Natl Def Med Ctr Natl Def Med Ctr, Sch Publ Hlth Triserv Gen Hosp, Teaching Off, Natl Def Med Ctr Fu Jen Catholic Univ, Dept Med, Coll Med Fu Jen Catholic Univ, Big Data Res Ctr, Coll Med Chi Mei Med Ctr, Dept Surg, Div Colorectal Surg Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Fu Jen Catholic Univ, Dept Publ Hlth, Coll Med
Keywords:	Colorectal cancer Gastroesophageal reflux disease National Health Insurance Research Database Retrospective cohort study
Date:	2021
Issue Date:	2023-11-11 11:52:41 (UTC+8)
Publisher:	SPRINGER
Abstract:	Purpose Several studies have investigated the association between gastroesophageal reflux disease (GERD) and colorectal cancer (CRC) risk, but the presented scientific results are highly debatable. This study examined the longitudinal association between GERD and CRC in an Asian population. Methods A retrospective cohort study was performed using the National Health Insurance Research Database of Taiwan. The study cohort comprised 45,828 individuals with newly diagnosed GERD (the GERD cohort) and 229,140 age, sex, and date of enrollment-matched patients without GERD (the comparison cohort) from 2000 to 2006. The primary outcome was the incidence of CRC. To estimate the effect of GERD on the risk of CRC, the Cox proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results There were 785 newly diagnosed CRC patients in the 45,828 patients with GERD. Relatively, there were 2375 incident CRC cases in 229,140 patients without GERD. The incidence rate of CRC for the GERD cohort (17.60 per 10,000 person-years) was significantly higher than the corresponding incidence rate for the comparison cohort (10.22 per 10,000 person-years). After adjustment for confounders, GERD was associated with a significantly increased risk of CRC (adjusted HR,1.76; 95% CI, 1.62-2.90). Of note, a significant association between GERD and CRC risk was evident in both genders. Conclusions In conclusion, this nationwide population-based cohort study supports the hypothesis that GERD was associated with a significantly increased risk of CRC. Our findings warrant still further investigation of the underlying mechanisms related to carcinogenic effect of GERD on colorectal carcinoma.
Relation:	INT J COLORECTAL DIS, v.36, n.11, pp.2411-2418
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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