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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34434


    標題: A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
    作者: Hung, Kuo-Chuan
    Chiang, Min-Hsien
    Wu, Shao-Chun
    Chang, Ying-Jen
    Ho, Chun-Ning
    Wang, Li-Kai
    Chen, Jen-Yin
    Chen, Kee-Hsin
    Sun, Cheuk-Kwan
    貢獻者: Chi Mei Med Ctr, Dept Anesthesiol
    Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr
    Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol, Coll Med
    Chang Jung Christian Univ, Coll Hlth Sci
    Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing
    Taipei Med Univ, Cochrane Taiwan
    Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applic
    Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Dept Nursing
    E Da Hosp, Dept Emergency Med
    I Shou Univ, Coll Med
    關鍵字: REGIONAL PAIN SYNDROME
    BONE-MINERAL DENSITY
    OXIDATIVE STRESS
    ASCORBIC-ACID
    FRACTURE
    MECHANISMS
    EFFICACY
    MUSCLE
    日期: 2021
    上傳時間: 2023-11-11 11:52:34 (UTC+8)
    出版者: NATURE PORTFOLIO
    摘要: This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase databases from inception till March 2021 identified seven eligible randomized controlled trials with 1,361 participants. Forest plot revealed no significant difference in the functional outcomes at 6-12 months [standardized mean difference (SMD)=-0.00, 95% CI - 0.19 to 0.18, 467 patients], risk of overall complications (RR=0.98, 95% CI 0.68 to 1.39, 426 patients), and pain severity at 3-6 months (SMD=- 0.18, 95% CI - 0.49 to 0.12, 486 patients) between patients with and without oral vitamin C supplementation. Pooled analysis showed that vitamin C treatment reduced the risk of CRPS I regardless of dosage (RR=0.46, 95% CI 0.25 to 0.85, 1143 patients). In conclusion, the current meta-analysis demonstrated that oral vitamin C supplementation may reduce the risk of complex regional pain syndrome type I but did not improve the functional outcomes in orthopedic patients. Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.
    關聯: SCI REP-UK, v.11, n.1
    Appears in Collections:[保健營養系(所) ] 期刊論文

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