A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

doi:10.1038/s41598-021-88864-7

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Title:	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
Authors:	Hung, Kuo-Chuan Chiang, Min-Hsien Wu, Shao-Chun Chang, Ying-Jen Ho, Chun-Ning Wang, Li-Kai Chen, Jen-Yin Chen, Kee-Hsin Sun, Cheuk-Kwan
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol, Coll Med Chang Jung Christian Univ, Coll Hlth Sci Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing Taipei Med Univ, Cochrane Taiwan Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applic Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Dept Nursing E Da Hosp, Dept Emergency Med I Shou Univ, Coll Med
Keywords:	REGIONAL PAIN SYNDROME BONE-MINERAL DENSITY OXIDATIVE STRESS ASCORBIC-ACID FRACTURE MECHANISMS EFFICACY MUSCLE
Date:	2021
Issue Date:	2023-11-11 11:52:34 (UTC+8)
Publisher:	NATURE PORTFOLIO
Abstract:	This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase databases from inception till March 2021 identified seven eligible randomized controlled trials with 1,361 participants. Forest plot revealed no significant difference in the functional outcomes at 6-12 months [standardized mean difference (SMD)=-0.00, 95% CI - 0.19 to 0.18, 467 patients], risk of overall complications (RR=0.98, 95% CI 0.68 to 1.39, 426 patients), and pain severity at 3-6 months (SMD=- 0.18, 95% CI - 0.49 to 0.12, 486 patients) between patients with and without oral vitamin C supplementation. Pooled analysis showed that vitamin C treatment reduced the risk of CRPS I regardless of dosage (RR=0.46, 95% CI 0.25 to 0.85, 1143 patients). In conclusion, the current meta-analysis demonstrated that oral vitamin C supplementation may reduce the risk of complex regional pain syndrome type I but did not improve the functional outcomes in orthopedic patients. Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.
Relation:	SCI REP-UK, v.11, n.1
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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