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| 標題: | Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo |
| 作者: | Huang, Nan-Chieh
Huang, Ru-Lai
Huang, Xiao-Fan
Chang, Kai-Fu
Lee, Chien-Ju
Hsiao, Chih-Yen
Lee, Shan-Chih
Tsai, Nu-Man |
| 貢獻者: | I Shou Univ, Dept Informat Engn
Kaohsiung Armed Forces Gen Hosp, Div Family Med, Zuoying Branch
Ditmanson Med Fdn Chia Yi Christian Hosp, Div Endocrinol & Metab, Dept Internal Med
Chung Shan Med Univ, Dept Med Lab & Biotechnol
Ditmanson Med Fdn Chia Yi Christian Hosp, Div Nephrol, Dept Internal Med
Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm
Chung Shan Med Univ, Dept Med Imaging & Radiol Sci
Chung Shan Med Univ Hosp, Dept Med Imaging
Chung Shan Med Univ Hosp, Clin Lab |
| 關鍵字: | ANTIOXIDANT PROPERTIES
CANCER PREVENTION
OXIDATIVE STRESS
ESSENTIAL OIL
ALPHA-PINENE
D-LIMONENE
EXPRESSION
TERPINOLENE
INHIBITION
ACTIVATION |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:49:50 (UTC+8) |
| 出版者: | PORTLAND PRESS LTD |
| 摘要: | Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found that plant extracts seem to be a reliable choice due to their multitarget effects against HCC. Juniperus communis has been used for centuries in traditional medicine and its anticancer properties have been reported. As a result, the purpose of the study was to investigate the anticancer effect and mechanism of J. communis extract (JCo extract) on HCC in vitro and in vivo. In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G0/G1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover, the combinational treatment of JCo and VP-16 was found to enhance the anticancer effect, revealing that JCo extract might have the potential to be utilized as an adjuvant to promote HCC treatment. Furthermore, in vivo study, JCo extract significantly suppressed HCC tumor growth and extended the lifespan with no or low systemic and pathological toxicity. JCo extract significantly up-regulated the expression of pro-apoptotic proteins and tumor suppressor p53, suppressed VEGF/VEGFR autocrine signaling, down-regulated cell cycle regulatory proteins and MMP2/MMP9 proteins. Overall, our results provide a basis for exploiting JCo extract as a potential anticancer agent against HCC. |
| 關聯: | BIOSCIENCE REP, v.41, n.7, BSR20211143 |
| 顯示於類別: | [醫務管理系(所)] 期刊論文
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