Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo

doi:10.1042/BSR20211143

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Title:	Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo
Authors:	Huang, Nan-Chieh Huang, Ru-Lai Huang, Xiao-Fan Chang, Kai-Fu Lee, Chien-Ju Hsiao, Chih-Yen Lee, Shan-Chih Tsai, Nu-Man
Contributors:	I Shou Univ, Dept Informat Engn Kaohsiung Armed Forces Gen Hosp, Div Family Med, Zuoying Branch Ditmanson Med Fdn Chia Yi Christian Hosp, Div Endocrinol & Metab, Dept Internal Med Chung Shan Med Univ, Dept Med Lab & Biotechnol Ditmanson Med Fdn Chia Yi Christian Hosp, Div Nephrol, Dept Internal Med Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm Chung Shan Med Univ, Dept Med Imaging & Radiol Sci Chung Shan Med Univ Hosp, Dept Med Imaging Chung Shan Med Univ Hosp, Clin Lab
Keywords:	ANTIOXIDANT PROPERTIES CANCER PREVENTION OXIDATIVE STRESS ESSENTIAL OIL ALPHA-PINENE D-LIMONENE EXPRESSION TERPINOLENE INHIBITION ACTIVATION
Date:	2021
Issue Date:	2023-11-11 11:49:50 (UTC+8)
Publisher:	PORTLAND PRESS LTD
Abstract:	Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found that plant extracts seem to be a reliable choice due to their multitarget effects against HCC. Juniperus communis has been used for centuries in traditional medicine and its anticancer properties have been reported. As a result, the purpose of the study was to investigate the anticancer effect and mechanism of J. communis extract (JCo extract) on HCC in vitro and in vivo. In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G0/G1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover, the combinational treatment of JCo and VP-16 was found to enhance the anticancer effect, revealing that JCo extract might have the potential to be utilized as an adjuvant to promote HCC treatment. Furthermore, in vivo study, JCo extract significantly suppressed HCC tumor growth and extended the lifespan with no or low systemic and pathological toxicity. JCo extract significantly up-regulated the expression of pro-apoptotic proteins and tumor suppressor p53, suppressed VEGF/VEGFR autocrine signaling, down-regulated cell cycle regulatory proteins and MMP2/MMP9 proteins. Overall, our results provide a basis for exploiting JCo extract as a potential anticancer agent against HCC.
Relation:	BIOSCIENCE REP, v.41, n.7, BSR20211143
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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