Sugammadex induced bradycardia and hypotension A case report and literature review

doi:10.1097/MD.0000000000026796

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/34388

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34388

Title:	Sugammadex induced bradycardia and hypotension A case report and literature review
Authors:	Teng, I-Chia Chang, Ying-Jen Lin, Yao-Tsung Chu, Chin-Chen Chen, Jen-Yin Wu, Zhi-Fu
Contributors:	Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Anesthesiol Tri Serv Gen Hosp Natl Def Med Ctr, Dept Anesthesiol
Keywords:	bradycardia cardiac arrest hypotension sugammadex
Date:	2021
Issue Date:	2023-11-11 11:48:52 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Rationale: There is evidence that sugammadex can facilitate extubation post-surgery and attenuate postoperative pulmonary complications resulting from postoperative residual neuromuscular blockade. However, it may induce adverse effects, including bronchospasm, laryngospasm, bradycardia, hypotension, and cardiac arrest. Here, we present a case of sugammadex-induced bradycardia and hypotension. Patient concerns: An 82-year-old female received video-assisted thoracic surgery decortication and wedge resection of the lung for empyema. Post-surgery, she developed bradycardia, hypotension, hypoxia, and weakness. Diagnoses: The patient was suspected to have sugammadex-induced bradycardia, hypotension, hypoxia and weakness. Interventions: The patient received immediate treatment with atropine (0.5 mg) for bradycardia. Glycopyrrolate (0.1 mg) and neostigmine (1 mg) were administered to improve the train-of-four (TOF) ratio. Outcomes: Following initial management, we observed improvement in the hemodynamics of the patient. She was discharged without any sequelae. Lessons: Sugammadex-induced bradycardia or cardiac arrest are rare; however, anesthesiologists must consider the possibility of the occurrence of such events and initiate appropriate management measures. Immediate treatment with atropine and inotropic or vasopressors is warranted if the patient presents with bradycardia.
Relation:	MEDICINE, v.100, n.30
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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