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| 標題: | Autophagy drives plasticity and functional polarization of tumor-associated macrophages |
| 作者: | Kuo, Wan-Ting
Chang, Jia-Ming
Chen, Chien-Chin
Tsao, Nina
Chang, Chih-Peng |
| 貢獻者: | Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med
Chia Yi Christian Hosp, Div Thorac Surg, Dept Surg
Asia Univ, Dept Phys Therapy, Coll Med & Hlth Sci
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
ChiaYi Christian Hosp, Dept Pathol, Ditmanson Med Fdn
Shou Univ, Dept Med Lab Sci, Coll Med
Natl Cheng Kung Univ, Dept Microbiol Immunol, Coll Med |
| 關鍵字: | autophagy
inflammation
LC3-associated phagocytosis
macrophage polarization
tumor-associated macrophages |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:48:05 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment (TME) and are key cells in regulating tumor development, metastasis, immune responses, inflammation, and chemoresistance. In response to TME stimulation, circulating monocytes are recruited and differentiated as TAMs. Most TAMs are defined as alternatively activated (M2) phenotype to create immunosuppressive TME and support tumor progression. In contrast, classically activated (M1) TAMs can produce pro-inflammatory cytokines and enhance immune responses against tumor development. Autophagy is a conserved catabolic process to control cellular homeostasis and biological function. Emerging evidence reveals crucial contribution of autophagy in modulating TAM plasticity and functional polarization in TME. In this review, we introduce the current understanding of autophagy-regulated TAM function in development of cancer. We focus on how autophagy modulates antigen presentation, LC3-associated phagocytosis, cytokine secretion, inflammasome regulation, recruitment, differentiation, and polarization of TAMs and suggest strategies for potential therapeutics by targeting autophagy in TAMs. We expect this review can provide a new notion of future cancer immunotherapy. |
| 關聯: | IUBMB LIFE, v.74, n.2, pp.157-169 SI |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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