Autophagy drives plasticity and functional polarization of tumor-associated macrophages

doi:10.1002/iub.2543

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/34374

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34374

Title:	Autophagy drives plasticity and functional polarization of tumor-associated macrophages
Authors:	Kuo, Wan-Ting Chang, Jia-Ming Chen, Chien-Chin Tsao, Nina Chang, Chih-Peng
Contributors:	Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med Chia Yi Christian Hosp, Div Thorac Surg, Dept Surg Asia Univ, Dept Phys Therapy, Coll Med & Hlth Sci Chia Nan Univ Pharm & Sci, Dept Cosmet Sci ChiaYi Christian Hosp, Dept Pathol, Ditmanson Med Fdn Shou Univ, Dept Med Lab Sci, Coll Med Natl Cheng Kung Univ, Dept Microbiol Immunol, Coll Med
Keywords:	autophagy inflammation LC3-associated phagocytosis macrophage polarization tumor-associated macrophages
Date:	2021
Issue Date:	2023-11-11 11:48:05 (UTC+8)
Publisher:	WILEY
Abstract:	Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment (TME) and are key cells in regulating tumor development, metastasis, immune responses, inflammation, and chemoresistance. In response to TME stimulation, circulating monocytes are recruited and differentiated as TAMs. Most TAMs are defined as alternatively activated (M2) phenotype to create immunosuppressive TME and support tumor progression. In contrast, classically activated (M1) TAMs can produce pro-inflammatory cytokines and enhance immune responses against tumor development. Autophagy is a conserved catabolic process to control cellular homeostasis and biological function. Emerging evidence reveals crucial contribution of autophagy in modulating TAM plasticity and functional polarization in TME. In this review, we introduce the current understanding of autophagy-regulated TAM function in development of cancer. We focus on how autophagy modulates antigen presentation, LC3-associated phagocytosis, cytokine secretion, inflammasome regulation, recruitment, differentiation, and polarization of TAMs and suggest strategies for potential therapeutics by targeting autophagy in TAMs. We expect this review can provide a new notion of future cancer immunotherapy.
Relation:	IUBMB LIFE, v.74, n.2, pp.157-169 SI
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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