Effects of Carissa carandas Linn. Fruit, Pulp, Leaf, and Seed on Oxidation, Inflammation, Tyrosinase, Matrix Metalloproteinase, Elastase, and Hyaluronidase Inhibition

doi:10.3390/antiox10091345

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/34371

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標題:	Effects of Carissa carandas Linn. Fruit, Pulp, Leaf, and Seed on Oxidation, Inflammation, Tyrosinase, Matrix Metalloproteinase, Elastase, and Hyaluronidase Inhibition
作者:	Neimkhum, Waranya Anuchapreeda, Songyot Lin, Wei-Chao Lue, Shang-Chian Lee, Kuan-Han Chaiyana, Wantida
貢獻者:	Chiang Mai Univ, Fac Pharm, Dept Pharmaceut Sci Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Div Clin Microscopy Chiang Mai Univ, Res Ctr Pharmaceut Nanotechnol Chia Nan Univ Pharm & Sci, Dept Cosmet Sci Chia Nan Univ Pharm & Sci, Inst Cosmet Sci Chia Nan Univ Pharm & Sci, Dept Pharm
關鍵字:	Carissa carandas ursolic acid antioxidant anti-tyrosinase matrix metalloproteinases nuclear factor-kappa B interleukin human epidermal keratinocyte line
日期:	2021
上傳時間:	2023-11-11 11:47:56 (UTC+8)
出版者:	MDPI
摘要:	In this study, the potential of Carissa carandas Linn. as a natural anti-aging, antioxidant, and skin whitening agent was studied. Various parts of C. carandas, including fruit, leaf, seed, and pulp were sequentially extracted by maceration using n-hexane, ethyl acetate, and ethanol, respectively. High-performance liquid chromatography, Folin-Ciocalteu, and Dowd method were used to investigate their chemical compositions. The inhibitory activities of oxidation process, matrix metalloproteinases (MMPs), elastase, hyaluronidase, and tyrosinase were analyzed. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay in a human epidermal keratinocyte line (HaCaT). The results exhibited that ethyl acetate could extract the most ursolic acid from C. carandas, while ethanol could extract the most phenolics and flavonoids. The leaf extract had the highest content of ursolic acid, phenolics, and flavonoids. The leaf extracted with ethyl acetate (AL) had the highest ursolic acid content (411.8 mg/g extract) and inhibited MMP-1, NF-kappa B, and tyrosinase activity the most. Ursolic acid has been proposed as a key component in these biological activities. Although several C. carandas extracts are beneficial to human skin, AL has been proposed for use in cosmetics and cosmeceuticals due to its superior anti-wrinkle, anti-inflammation, and whitening properties.
關聯:	ANTIOXIDANTS-BASEL, v.10, n.9, pp.1345
显示于类别:	[化妝品應用與管理系(所)] 期刊論文 [藥學系(所)] 期刊論文

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