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    標題: Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages
    作者: Lee, Po-Yen
    Liu, Ching-Chih
    Wang, Shu-Chi
    Chen, Kai-Yin
    Lin, Tzu-Chieh
    Liu, Po-Len
    Chiu, Chien-Chih
    Chen, I-Chen
    Lai, Yu-Hung
    Cheng, Wei-Chung
    Chung, Wei-Ju
    Yeh, Hsin-Chih
    Huang, Chi-Han
    Su, Chia-Cheng
    Huang, Shu-Pin
    Li, Chia-Yang
    貢獻者: Kaohsiung Med Univ, Coll Med, Grad Inst Med
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol
    Chi Mei Med Ctr, Dept Ophthalmol
    Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol
    Kaohsiung Med Univ, Div Cardiol, Dept Internal Med
    Kaohsiung Med Univ, Coll Med, Dept Resp Therapy
    Kaohsiung Med Univ, Dept Biotechnol
    Kaohsiung Med Univ Hosp, Dept Pediat
    Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pediat
    Kaohsiung Med Univ, Coll Med, Sch Med, Dept Ophthalmol
    China Med Univ, Grad Inst Biomed Sci, Res Ctr Tumor Med Sci
    China Med Univ & Acad Sinica, PhD Program Canc Biol & Drug Discovery
    Kaohsiung Med Univ, Coll Med, Sch Med, Dept Urol
    Kaohsiung Municipal TaTung Hosp, Dept Urol, Kaohsiung 80145, Taiwan;[Su, Chia-Cheng
    Chi Mei Med Ctr, Div Urol, Dept Surg
    Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Urol
    Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med
    Kaohsiung Med Univ Hosp, Dept Med Res
    關鍵字: zearalenone
    mycotoxin
    innate immunity
    NLRP3 inflammasome
    macrophages
    日期: 2021
    上傳時間: 2023-11-11 11:47:54 (UTC+8)
    出版者: MDPI
    摘要: Zearalenone (ZEA) is a mycotoxin that has several adverse effects on most mammalian species. However, the effects of ZEA on macrophage-mediated innate immunity during infection have not been examined. In the present study, bacterial lipopolysaccharides (LPS) were used to induce the activation of macrophages and evaluate the effects of ZEA on the inflammatory responses and inflammation-associated signaling pathways. The experimental results indicated that ZEA suppressed LPS-activated inflammatory responses by macrophages including attenuating the production of proinflammatory mediators (nitric oxide (NO) and prostaglandin E-2 (PGE(2))), decreased the secretion of proinflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6), inhibited the activation of c-Jun amino-terminal kinase (JNK), p38 and nuclear factor-kappa B (NF-kappa B) signaling pathways, and repressed the nucleotide-binding and oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. These results indicated that mycotoxin ZEA attenuates macrophage-mediated innate immunity upon LPS stimulation, suggesting that the intake of mycotoxin ZEA-contaminated food might result in decreasing innate immunity, which has a higher risk of adverse effects during infection.
    關聯: TOXINS, v.13, n.9, pp.593
    Appears in Collections:[高齡福祉養生管理系] 期刊論文

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