Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages

doi:10.3390/toxins13090593

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Title:	Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages
Authors:	Lee, Po-Yen Liu, Ching-Chih Wang, Shu-Chi Chen, Kai-Yin Lin, Tzu-Chieh Liu, Po-Len Chiu, Chien-Chih Chen, I-Chen Lai, Yu-Hung Cheng, Wei-Chung Chung, Wei-Ju Yeh, Hsin-Chih Huang, Chi-Han Su, Chia-Cheng Huang, Shu-Pin Li, Chia-Yang
Contributors:	Kaohsiung Med Univ, Coll Med, Grad Inst Med Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol Chi Mei Med Ctr, Dept Ophthalmol Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol Kaohsiung Med Univ, Div Cardiol, Dept Internal Med Kaohsiung Med Univ, Coll Med, Dept Resp Therapy Kaohsiung Med Univ, Dept Biotechnol Kaohsiung Med Univ Hosp, Dept Pediat Kaohsiung Med Univ, Coll Med, Sch Med, Dept Pediat Kaohsiung Med Univ, Coll Med, Sch Med, Dept Ophthalmol China Med Univ, Grad Inst Biomed Sci, Res Ctr Tumor Med Sci China Med Univ & Acad Sinica, PhD Program Canc Biol & Drug Discovery Kaohsiung Med Univ, Coll Med, Sch Med, Dept Urol Kaohsiung Municipal TaTung Hosp, Dept Urol, Kaohsiung 80145, Taiwan;[Su, Chia-Cheng Chi Mei Med Ctr, Div Urol, Dept Surg Chia Nan Univ Pharm & Sci, Dept Senior Citizen Serv Management Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Urol Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med Kaohsiung Med Univ Hosp, Dept Med Res
Keywords:	zearalenone mycotoxin innate immunity NLRP3 inflammasome macrophages
Date:	2021
Issue Date:	2023-11-11 11:47:54 (UTC+8)
Publisher:	MDPI
Abstract:	Zearalenone (ZEA) is a mycotoxin that has several adverse effects on most mammalian species. However, the effects of ZEA on macrophage-mediated innate immunity during infection have not been examined. In the present study, bacterial lipopolysaccharides (LPS) were used to induce the activation of macrophages and evaluate the effects of ZEA on the inflammatory responses and inflammation-associated signaling pathways. The experimental results indicated that ZEA suppressed LPS-activated inflammatory responses by macrophages including attenuating the production of proinflammatory mediators (nitric oxide (NO) and prostaglandin E-2 (PGE(2))), decreased the secretion of proinflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6), inhibited the activation of c-Jun amino-terminal kinase (JNK), p38 and nuclear factor-kappa B (NF-kappa B) signaling pathways, and repressed the nucleotide-binding and oligomerization domain (NOD)-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. These results indicated that mycotoxin ZEA attenuates macrophage-mediated innate immunity upon LPS stimulation, suggesting that the intake of mycotoxin ZEA-contaminated food might result in decreasing innate immunity, which has a higher risk of adverse effects during infection.
Relation:	TOXINS, v.13, n.9, pp.593
Appears in Collections:	[Dept. of Senior Service and Health Management] Periodical Articles

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