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| 標題: | Postoperative Drip-Infusion of Remifentanil Reduces Postoperative Pain-A Retrospective Observative Study |
| 作者: | Huang, Yi-Hsuan
Lee, Meei-Shyuan
Lin, Yao-Tsung
Huang, Nian-Cih
Kao, Jing
Lai, Hou-Chuan
Lin, Bo-Feng
Cheng, Kuang-, I
Wu, Zhi-Fu |
| 貢獻者: | Natl Def Med Ctr, Triserv Gen Hosp, Dept Anesthesiol
Natl Def Med Ctr, Sch Publ Hlth
Chi Mei Med Ctr, Dept Anesthesiol
Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Anesthesiol
Kaohsiung Med Univ, Coll Med, Fac Med, Dept Anesthesiol |
| 關鍵字: | remifentanil
hyperalgesia
drip infusion
gradual withdrawal |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:47:46 (UTC+8) |
| 出版者: | MDPI |
| 摘要: | Development of remifentanil-induced hyperalgesia (RIH) postoperatively is an unpleasant experience that requires further treatment. This study assessed the effects of gradual withdrawal combined with drip infusion of remifentanil on postoperative pain and the requirement for rescue analgesics. A total of 559 patients receiving total intravenous anesthesia with propofol and remifentanil were enrolled. All patients either underwent gradual withdrawal of remifentanil (GWR) or gradual withdrawal combined with drip infusion (GWDR) with a dose of 1 mcg center dot kg(-1) for 30 min after extubation. The numeric rating scale (NRS) and the requirement of rescue analgesics were assessed. The requirement for rescue analgesics was significantly lower in the GWDR group than in the GWR group (13.2% vs. 35.7%; p < 0.001). At the post-anesthetic care unit (PACU), patients in the GWDR group had a lower NRS pain score (p < 0.001). In addition, in the postoperative 2nd hour, patients in the GWDR group had a significantly lower NRS than the GWR group (beta, -0.31; p = 0.003). No remifentanil-related adverse effects were observed. We found that gradual withdrawal combined with drip infusion of remifentanil required less rescue analgesics and reduced pain scores. The new way of remifentanil administration may be effective to prevent RIH. |
| 關聯: | INT J ENV RES PUB HE, v.18, n.17, pp.9225 |
| 顯示於類別: | [ 食品科技系 ] 期刊論文
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