Postoperative Drip-Infusion of Remifentanil Reduces Postoperative Pain-A Retrospective Observative Study

doi:10.3390/ijerph18179225

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/34367

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/34367

Title:	Postoperative Drip-Infusion of Remifentanil Reduces Postoperative Pain-A Retrospective Observative Study
Authors:	Huang, Yi-Hsuan Lee, Meei-Shyuan Lin, Yao-Tsung Huang, Nian-Cih Kao, Jing Lai, Hou-Chuan Lin, Bo-Feng Cheng, Kuang-, I Wu, Zhi-Fu
Contributors:	Natl Def Med Ctr, Triserv Gen Hosp, Dept Anesthesiol Natl Def Med Ctr, Sch Publ Hlth Chi Mei Med Ctr, Dept Anesthesiol Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Anesthesiol Kaohsiung Med Univ, Coll Med, Fac Med, Dept Anesthesiol
Keywords:	remifentanil hyperalgesia drip infusion gradual withdrawal
Date:	2021
Issue Date:	2023-11-11 11:47:46 (UTC+8)
Publisher:	MDPI
Abstract:	Development of remifentanil-induced hyperalgesia (RIH) postoperatively is an unpleasant experience that requires further treatment. This study assessed the effects of gradual withdrawal combined with drip infusion of remifentanil on postoperative pain and the requirement for rescue analgesics. A total of 559 patients receiving total intravenous anesthesia with propofol and remifentanil were enrolled. All patients either underwent gradual withdrawal of remifentanil (GWR) or gradual withdrawal combined with drip infusion (GWDR) with a dose of 1 mcg center dot kg(-1) for 30 min after extubation. The numeric rating scale (NRS) and the requirement of rescue analgesics were assessed. The requirement for rescue analgesics was significantly lower in the GWDR group than in the GWR group (13.2% vs. 35.7%; p < 0.001). At the post-anesthetic care unit (PACU), patients in the GWDR group had a lower NRS pain score (p < 0.001). In addition, in the postoperative 2nd hour, patients in the GWDR group had a significantly lower NRS than the GWR group (beta, -0.31; p = 0.003). No remifentanil-related adverse effects were observed. We found that gradual withdrawal combined with drip infusion of remifentanil required less rescue analgesics and reduced pain scores. The new way of remifentanil administration may be effective to prevent RIH.
Relation:	INT J ENV RES PUB HE, v.18, n.17, pp.9225
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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