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| 標題: | The potential of Streptococcus thermophiles (TCI633) in the anti-aging |
| 作者: | Liu, Cheng
Tseng, Ya-Ping
Chan, Leong-Perng
Liang, Chia-Hua |
| 貢獻者: | Dept Hlth & Beauty, Kaoh
Dept Optometry
Shu Zen Jr Coll Med & Management, Dept Dent Technol
Natl Cheng Kung Univ, Inst Basic Med Sci
Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Otorhinolaryngol Head & Neck Surg
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Coll Med, Dept Otorhinolaryngol Head & Neck Surg,Fac Med
Chia Nan Univ Pharm & Sci, Dept Cosmet Sci
Chia Nan Univ Pharm & Sci, Inst Cosmet Sci |
| 關鍵字: | anti-aging
skin
Streptococcus thermophiles |
| 日期: | 2021 |
| 上傳時間: | 2023-11-11 11:46:36 (UTC+8) |
| 出版者: | WILEY |
| 摘要: | Background Streptococcus thermophilus (TCI633) is a probiotic that has been newly isolated from human breast milk, and it can produce hyaluronic acid (HA) when colonizing the gastrointestinal (GI) tract of rodents and humans. A recent study has the established that TCI633 can alleviate synovial tissue inflammation and has potential to mitigate the progression of osteoarthritis. Objective TCI633 has not been available for use in skincare and this preliminary clinical study will assess its improvement of the skin. Methods In this study, DNA protection, Hyaluronidase assay, cell viability, and collagen synthesis on human fibroblasts of TCI633 were assessed. Subjects were enrolled in this clinical study and randomly assigned to the TCI633 or placebo group. Each subject was informed to intake two tablets daily for 8 weeks. Each subject was required to undergo skin condition inspection at weeks 0, 4, and 8 and hematology tests to monitor HA, superoxide dismutase (SOD) and catalase levels, and kidney and liver function at weeks 0 and 8. Results The effects of TCI633 supplementation, including the promotion of skin cell proliferation, the increase of their collagen content, their protection against DNA damage, and the inhibition of hyaluronidase activities, are investigated. Subjects were recruited for an 8-week long clinical trial to confirm the efficacy of TCI633 in improving the serum biochemical HA, SOD and catalase levels, and anti-skin age markers. Conclusions This work provides an alternative approach to improving health, indicating the potential of TCI633 supplementation to delay the aging of skin and improve its condition. |
| 關聯: | J COSMET DERMATOL-US, v.21, n.6, pp.2635-2647 |
| 顯示於類別: | [化妝品應用與管理系(所)] 期刊論文
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